{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:23Z","timestamp":1786978283057,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,10,29]],"date-time":"2003-10-29T00:00:00Z","timestamp":1067385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recurrent non\u2010cerebellar primitive neuroectodermal tumors (PNETs) carry a dismal prognosis when treated with conventional chemotherapy alone. XSWe tested the efficacy of high\u2010dose chemotherapy (HDC) followed by autologous stem\u2010cell rescue (ASCR) in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>\n                      Eligibility mandated either minimal residual disease or evidence of chemosensitivity before HDC. Conditioning consisted of carboplatin (CBDCA) (500 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      or AUC\u2009= 7 mg\/ml min using the Calvert formula) on days \u22128 to \u22126, thiotepa (300 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), and etoposide (250 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) on days \u22125 to \u22123. Irradiation was given post HDC selectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 17 patients treated in this study, there were eight pineoblastoma(s) (pineo), seven cortical PNETs, and two arising elsewhere. Relapse was either local (nine) or metastatic to the brain (four) or spine (four). Two patients received HDC as the sole therapy for recurrence; additionally, eight underwent surgical debulking before HDC, and nine received irradiation, including six after HDC. Median age at ASCR was 3.9 years. Two patients died of toxicity (11%) and ten experienced tumor relapse (range: 23\u2013361 days post ASCR). Five patients with cortical PNETs remain alive disease\u2010free (median follow\u2010up: 8.3 years); four of them received irradiation post HDC. The difference in 5\u2010year event\u2010free survival (EFS) between patients with pineo and other supratentorial PNETs was significant (0 vs. 62.5\u2009\u00b1\u200917%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0065). Both surgery at relapse and irradiation post HDC were favorable prognostic factors (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006 and 0.01, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with recurrent cortical PNETs can be cured with this strategy. Surgical debulking before, and irradiation after HDC play an important role in treatment success. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.10369","type":"journal-article","created":{"date-parts":[[2004,1,27]],"date-time":"2004-01-27T07:03:57Z","timestamp":1075187037000},"page":"261-267","source":"Crossref","is-referenced-by-count":60,"title":["High\u2010dose chemotherapy with autologous stem\u2010cell rescue in the treatment of patients with recurrent non\u2010cerebellar primitive neuroectodermal tumors"],"prefix":"10.1002","volume":"42","author":[{"given":"Alberto","family":"Broniscer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore P.","family":"Nicolaides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira J.","family":"Dunkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sposto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Finlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.8.1607"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.7.1687"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000028717"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000501)88:9<2189::AID-CNCR27>3.0.CO;2-G"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.6.1377"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00165520"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003810050418"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.5.1045"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80662-0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.1.62"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199606)26:6<387::AID-MPO3>3.0.CO;2-D"},{"key":"e_1_2_1_13_2","first-page":"227","article-title":"High\u2010dose busulfan and thiotepa with autologous bone marrow transplantation in childhood malignant brain tumors: A phase II study","volume":"9","author":"Kalifa C","year":"1992","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.2.382"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003810050142"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.5.1814"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1043887"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.9.2495"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.7.2486"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006383400353"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.11.1748"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1976.220"},{"key":"e_1_2_1_24_2","first-page":"163","article-title":"Evaluation of survival data and two new rank order statistics arising in its consideration","volume":"50","author":"Mantel N","year":"1966","journal-title":"Cancer Chemother Rep"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.222"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980801)83:3<566::AID-CNCR27>3.0.CO;2-T"}],"container-title":["Pediatric Blood &amp; 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