{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:44:44Z","timestamp":1793378684592,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,11,25]],"date-time":"2003-11-25T00:00:00Z","timestamp":1069718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>For hepatoblastoma (HB) that remains unresectable by partial hepatectomy after chemotherapy, total hepatectomy with orthotopic liver transplantation (LTX) has been advocated as the best treatment option. The role of LTX in the overall management of HB is still, however, unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>The results of LTX from the first study of HB by the International Society of Pediatric Oncology, SIOPEL\u20101, were analyzed. In addition, the world experience of LTX for HB was extensively reviewed. Twelve patients in the SIOPEL\u20101 study underwent a LTX. Median (range) follow\u2010up at Dec. 31, 2001 was 117 months (52\u2013125) since LTX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall survival at 10 years post\u2010LTX was 85% for the seven children who received a \u201cprimary LTX\u201d and 40% for the 5 children who underwent a \u201crescue LTX\u201d after previous partial hepatectomy. In the world experience (147 cases), the overall survival rate at 6 year post\u2010LTX was 82% for 106 patients who received a \u201cprimary LTX\u201d and 30% for 41 patients who underwent a \u201crescue LTX.\u201d Multivariate analysis of patients undergoing primary LTX showed that only macroscopic venous invasion had a significant impact (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value: 0.045 with a hazard ratio of 2.96) on overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Orthotopic LTX has added a new dimension to the treatment of HB unresectable by partial hepatectomy. Because of the rarity of the disease and to optimize results, children with extensive HB should be treated in centers with surgical expertise in pediatric major liver resection and LTX, in close collaboration with pediatric oncologists, radiologists, and histopathologists. Pediatr Blood Cancer 2004;42:74\u201383. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.10376","type":"journal-article","created":{"date-parts":[[2003,12,2]],"date-time":"2003-12-02T09:31:22Z","timestamp":1070357482000},"page":"74-83","source":"Crossref","is-referenced-by-count":294,"title":["Liver transplantation for hepatoblastoma: Results from the International Society of Pediatric Oncology (SIOP) study SIOPEL\u20101 and review of the world 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