{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T01:18:42Z","timestamp":1709860722655},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,11,5]],"date-time":"2003-11-05T00:00:00Z","timestamp":1067990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Detection of Philadelphia chromosome (Ph) in childhood T\u2010lineage acute lymphoproliferative disorders is a rare event. Additional cytogenetic abnormalities are particularly uncommon in ALL. We here report two cases with T lineage acute lymphoproliferative disorders (T\u2010ALL and T\u2010NHL) presenting with both cytogenetic alterations and <jats:italic>BCR\u2010ABL<\/jats:italic> fusion transcripts, associated with an aggressive presentation and a poor outcome. We point out firstly on the cytogenetic aberrations, supporting the hypothesis of multi\u2010lineage involvement of ALL expressing Ph chromosome; secondly, on the persistence of T\u2010cell leukemic clone detected by minimal residual disease (MRD) analysis, despite of the early disappearance of <jats:italic>BCR\u2010ABL<\/jats:italic> fusion transcript. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.10453","type":"journal-article","created":{"date-parts":[[2004,1,27]],"date-time":"2004-01-27T12:03:57Z","timestamp":1075205037000},"page":"278-280","source":"Crossref","is-referenced-by-count":9,"title":["Association of cytogenetic abnormalities with detection of BCR\u2010ABL fusion transcripts in children with T\u2010lineage lymphoproliferative diseases (T\u2010ALL and T\u2010NHL)"],"prefix":"10.1002","volume":"42","author":[{"given":"Luca","family":"Lo Nigro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Sainati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Mirabile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Lanciotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Poli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Leszl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Basso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,11,5]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"665","article-title":"Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia","volume":"4","author":"Lim LC","year":"1999","journal-title":"Int J Mol Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401592"},{"key":"e_1_2_1_4_2","first-page":"1314","article-title":"Application of a chemiluminescent methodology for detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukemia (ALL)","volume":"86","author":"Lo Nigro L","year":"2001","journal-title":"Haematologica"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.2.420"},{"key":"e_1_2_1_7_2","first-page":"856","article-title":"BCR\u2010ABL rearrangement in adult T\u2010lineage acute lymphoblastic leukemia","volume":"83","author":"Fabbiano F","year":"1998","journal-title":"Haematologica"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050412"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1182\/blood.V87.4.1532.bloodjournal8741532","article-title":"Clinical features and outcome of children with first marrow relapse of acute lymphoblastic leukemia expressing BCR\u2010ABL fusion transcripts","volume":"87","author":"Beyermann B","year":"1996","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199906)32:6<455::AID-MPO15>3.0.CO;2-S"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1182\/blood.V90.3.1226","article-title":"Detectable molecular residual disease at the beginning of maintenance therapy indicates poor outcome in children with T\u2010cell acute lymphoblastic leukemia","volume":"90","author":"Dibenedetto SP","year":"1997","journal-title":"Blood"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.10453","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.10453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T01:14:47Z","timestamp":1700183687000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.10453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,5]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1002\/pbc.10453"],"URL":"https:\/\/doi.org\/10.1002\/pbc.10453","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,5]]}}}