{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:28:17Z","timestamp":1791102497653,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T00:00:00Z","timestamp":1080172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We reviewed 56 IRS\u2010IV patients with localized rhabdomyosarcoma [RMS] of the retroperitoneum\/pelvis to assess outcome and prognostic factors, including the value of initially excising \u226550% of the tumor (debulking) before chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients had embryonal RMS [N=38], alveolar RMS [N\u2009=\u20097], RMS not otherwise specified [NOS, N\u2009=\u20097], or undifferentiated sarcoma [N\u2009=\u20094]. Fifteen patients were debulked; 41 patients were biopsied. All received VAC; most received radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Estimated 5\u2010year failure\u2010free survival [FFS] and overall survival rates were 70 and 75%, respectively. FFS rates were better for patients &lt;10 years old and those with embryonal RMS compared to alveolar RMS\/undifferentiated sarcoma. After adjusting for age and histological differences, FFS was better for patients whose tumor was debulked prior to beginning therapy [<jats:italic>P<\/jats:italic>\u2009=\u20090.02].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results are superior to those of previous protocols for patients with RMS of the retroperitoneum\/pelvis. Initial excision of \u226550% of the tumor may be associated with increased FFS. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20012","type":"journal-article","created":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T22:01:14Z","timestamp":1080252074000},"page":"618-625","source":"Crossref","is-referenced-by-count":37,"title":["Results of treatment of fifty\u2010six patients with localized retroperitoneal and pelvic rhabdomyosarcoma: A report from The Intergroup Rhabdomyosarcoma Study\u2010IV, 1991\u20131997"],"prefix":"10.1002","volume":"42","author":[{"given":"R. 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