{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:37:18Z","timestamp":1778625438976,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,2,13]],"date-time":"2004-02-13T00:00:00Z","timestamp":1076630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Young adults who are long\u2010term survivors of acute lymphoblastic leukaemia (ALL) in early childhood usually do well and do not have to go to regular medical checkups. Many of these survivors did receive prophylactic cranial radiotherapy during their oncological treatment. The effect of cranial irradiation on the hypothalamus is considered to be progressive. Therefore, late effects, such as reduced growth hormone (GH) secretion, may remain undetected until adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Records from all patients treated for ALL before the onset of puberty in the region of West Sweden, between 1 January 1973 and 31 December 1985 were included, provided they were in first remission with a minimum follow\u2010up time of 15 years, and a minimum age of 20. These criteria were met by 47 young adults aged 20\u201332 years, of whom 35 agreed to participate. We studied spontaneous GH secretion over 24 hr, IGF\u2010I and IGFBP\u20103, final height and BMI. The patients had been treated according to three consecutive Swedish childhood leukaemia group protocols. The median follow\u2010up time was 20 years, and 19 of the patients had been treated with cranial irradiation (CRT+), 16 had not (CRT\u2212).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CRT+ patients had significantly lower maximal peaks of GH than CRT\u2212 patients. Fifty percent of the CRT+ patients had a GH<jats:sub>max<\/jats:sub> below the cut\u2010off level (3.3 \u03bcg\/l), for GH treatment. CRT\u2212 patients all had GH<jats:sub>max<\/jats:sub> levels considered within the normal range. Final height of all the patients, except one CRT+ women, was in the range of expected midparental height, the median loss in final height in the CRT+ patients was 0.8 standard deviation (SD). No patient in this study was obese by definition (BMI &lt;30 kg\/m<jats:sup>2<\/jats:sup>). IGF\u2010I and IGFBP\u20103 concentrations did not correlate to variations in spontaneous GH secretion in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In spite of the little effect on final height, we found impaired spontaneous GH secretion in 79% of young adults 20\u201332 years of age, and GH deficiency (GHD) in 47% after low\u2010dose cranial irradiation in early childhood. The consequences of this low\u2010GH secretion need to be investigated. Pediatr Blood Cancer 2004;42:582\u2013588. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20020","type":"journal-article","created":{"date-parts":[[2004,4,28]],"date-time":"2004-04-28T23:01:03Z","timestamp":1083193263000},"page":"582-588","source":"Crossref","is-referenced-by-count":17,"title":["Young adult survivors of childhood acute lymphoblastic leukemia: Spontaneous GH secretion in relation to CNS radiation"],"prefix":"10.1002","volume":"42","author":[{"given":"M.","family":"Jarfelt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bjarnason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Lannering","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401961"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01856.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00427-M"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199806)30:6<351::AID-MPO9>3.0.CO;2-D"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.3.669"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01860.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.77.6.1671"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92328-3"},{"issue":"8","key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1210\/jcem.84.8.5916","article-title":"The 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