{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:25:24Z","timestamp":1773458724079,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,3,3]],"date-time":"2004-03-03T00:00:00Z","timestamp":1078272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our objectives were to describe the frequency and determine risk factors for hearing deterioration following pediatric stem cell transplantation (SCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective cohort study, we performed pure tone audiometry and measured otoacoustic emissions (OAE) prior to and following SCT. Worse hearing was considered deterioration in either audiometry or OAE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between October 2000 and November 2002, 45 informative audiometry or OAE results were obtained. Hearing deteriorated following SCT in 20\/45 (44%) of these children. Those with worse hearing following SCT were more likely to have neuroblastoma (odds ratio [OR] 16.0 [95% CI 1.8, 143.2; <jats:italic>P<\/jats:italic>\u2009=\u20090.003]), receive carboplatin conditioning (OR 7.7 [95% CI 1.4, 41.9; <jats:italic>P<\/jats:italic>\u2009=\u20090.01]), have abnormal baseline hearing (OR 5.1 [95% CI 1.3, 19.5; <jats:italic>P<\/jats:italic>\u2009=\u20090.02]), and have higher baseline serum creatinine (OR for every increase of 5 \u03bcmol\/L of serum creatinine of 1.5 [95% CI 1.03, 2.1; <jats:italic>P<\/jats:italic>\u2009=\u20090.03]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Many children who undergo SCT will have deterioration in hearing following SCT. A high\u2010risk group of children can be delineated who may bene fit from more intensive audiological monitoring following SCT. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20036","type":"journal-article","created":{"date-parts":[[2004,3,25]],"date-time":"2004-03-25T17:07:46Z","timestamp":1080234466000},"page":"598-603","source":"Crossref","is-referenced-by-count":34,"title":["Ototoxicity following pediatric hematopoietic stem cell transplantation: A prospective cohort study"],"prefix":"10.1002","volume":"42","author":[{"given":"Angela","family":"Punnett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Bliss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Lee","family":"Dupuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdolell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.6.754"},{"key":"e_1_2_6_3_2","first-page":"151","article-title":"Ototoxicity of carboplatin: Comparing animal and clinical models at the Hospital for Sick Children","volume":"23","author":"Macdonald MR","year":"1994","journal-title":"J Otolaryngol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199607)27:1<26::AID-MPO6>3.0.CO;2-W"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/sct.1990.6.145"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000120545"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg122"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/104345429801500402"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70201-X"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199911000-00016"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199007000-00008"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701831"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/149.1.23"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(93)90011-Q"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989811800504"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(01)00455-4"},{"key":"e_1_2_6_17_2","first-page":"257","article-title":"Monitoring and predicting ototoxic damage using distortion\u2010product otoacoustic emissions: Pediatric case study","volume":"9","author":"Littman TA","year":"1998","journal-title":"J Am Acad Audiol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/hn.1999.v121.a101567"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20036","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T12:51:37Z","timestamp":1700225497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,3]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1002\/pbc.20036"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20036","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,3]]}}}