{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T21:10:26Z","timestamp":1700255426526},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,5,17]],"date-time":"2004-05-17T00:00:00Z","timestamp":1084752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 5\u2010day\u2010old newborn presented with neonatal enteroviral infection. The patient's hospital course was complicated by acute liver dysfunction, renal insufficiency, fluid overload, respiratory failure, hypertension, catheter related thrombosis, <jats:italic>Klebsiella pneumoniae<\/jats:italic> sepsis, intracerebral and intraventricular hemorrhage, and disseminated intravascular coagulation (DIC). Administration of fresh frozen plasma (FFP) and cryoprecipitate failed to control the patient's hemostasis and led to significant fluid overload. Recombinant activated factor VII (rFVIIa, Novoseven\u00ae NovoNordisk, Bagsvaerd, Denmark) was given to the neonate as a bolus (rFVIIa at 60\u201380 \u03bcg\/kg body weight), followed by a continuous infusion (2.5\u201316 \u03bcg\/kg\/hr). Recombinant activated factor VII controlled hemostasis, until the patient's liver function recovered. The patient's blood product requirement significantly decreased and his fluid overload resolved. Administration of rFVIIa appears to have stabilized the coagulation process. The patient appears to have fully recovered from the infection's complications. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20078","type":"journal-article","created":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T07:00:48Z","timestamp":1084863648000},"page":"170-176","source":"Crossref","is-referenced-by-count":18,"title":["Management of coagulopathy with recombinant factor VIIa in a neonate with echovirus type 7"],"prefix":"10.1002","volume":"43","author":[{"given":"Jakica","family":"Tancabelic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven Edward","family":"Haun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365548909167452"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880260"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199110000-00016"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.3.523"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10024001-0043-0"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80304-9"},{"key":"e_1_2_5_8_2","first-page":"1486","volume-title":"Nathan and Oski's Hematology of Infancy and Childhood","author":"Esmon CT","year":"2003"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03437.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70013-1"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/104990910201900413"},{"key":"e_1_2_5_12_2","first-page":"S61","article-title":"Activated factor VII activates factors IX and X on the surface of activated platelets: Thoughts on the mechanism of action of high dose activated factor VII","volume":"1","author":"Hoffman M","year":"1998","journal-title":"Blood Coagul Fibrinolysis"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02870.x"},{"issue":"1","key":"e_1_2_5_14_2","first-page":"14","article-title":"The action of high dose factor VIIa (FVIIa) in a cell based model of hemostasis","volume":"49","author":"Hoffman M","year":"2003","journal-title":"Dis Mon"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1489-x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.1.169"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2001.11746589"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200004001-00019"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130478-200301000-00009"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83159-2"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200210000-00011"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20078","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T20:48:55Z","timestamp":1700254135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,17]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["10.1002\/pbc.20078"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20078","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,17]]}}}