{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T18:58:50Z","timestamp":1697655530806},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T00:00:00Z","timestamp":1087776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Given the heterogeneity of published data in US children, we sought to evaluate outcomes of a standardized immunosuppressive therapy (IST) regimen for severe aplastic anemia (SAA) at The Children's Hospital (Denver, CO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the records of 16 children diagnosed from 1990 to 2003 and treated by IST, among whom 14 received the standardized regimen of antithymocyte globulin (ATG) and cyclosporine A (CsA). Serial hematologic parameters, complications, transfusion requirements, and time to response were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One child who died from a pre\u2010existing <jats:italic>Aspergillus<\/jats:italic> infection prior to expected IST response was excluded from the analysis. Overall (transfusion\u2010independent) response to IST was 100% (13\/13), without any relapses or clinically evident leukemic\/myelodysplastic transformations after a median follow\u2010up time of 4.4 years (range: 10 months\u201313.3 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conlusions<\/jats:title><jats:p>This report documents excellent outcome using combination ATG and CsA IST for pediatric SAA. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20114","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T07:01:43Z","timestamp":1087887703000},"page":"718-722","source":"Crossref","is-referenced-by-count":12,"title":["Successful treatment of severe aplastic anemia in children using standardized immunosuppressive therapy with antithymocyte globulin and cyclosporine A"],"prefix":"10.1002","volume":"43","author":[{"given":"Neil A.","family":"Goldenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas K.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiayuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taru","family":"Hays","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90465-P"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03165112"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1182\/blood.V76.9.1748.1748","article-title":"The haemopoietic defect in aplastic anemia assessed by long term marrow culture","volume":"76","author":"March JCW","year":"1990","journal-title":"Blood"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1182\/blood.V87.8.3179.bloodjournal8783179","article-title":"Aplastic anemia: Evidence for dysfunctional bone marrow progenitors cells and the corrective effect of granulocyte colony\u2010stimulating factor in vitro","volume":"87","author":"Scopes J","year":"1996","journal-title":"Blood"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03134.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.d01-1989.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705083361906"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.10.3582"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02008.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.9.1130"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1134"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V48.1.63.63"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.6.2049"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1043875"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199703000-00004"},{"key":"e_1_2_6_17_2","first-page":"18","article-title":"Comparison of long\u2010term outcome of children with severe aplastic anemia treated with immunosuppression versus bone marrow transplantation","volume":"3","author":"Gillio AP","year":"1997","journal-title":"Biol Blood Marrow Transplant"},{"issue":"2","key":"e_1_2_6_18_2","first-page":"104","article-title":"Antithymocyte globulin, cyclosporine, and prednisone for the treatment of severa aplastic anemia in children: A pilot study","volume":"16","author":"Matloub YH","year":"1994","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702699"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.3.1009"}],"container-title":["Pediatric Blood &amp; 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