{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:22:41Z","timestamp":1765758161502},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,7,7]],"date-time":"2004-07-07T00:00:00Z","timestamp":1089158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to describe the health status experienced by young children during various phases of therapy for advanced neuroblastoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen patients aged 2.00\u20134.99 years at the time of diagnosis of neuroblastoma (stages 3 or 4) who received active therapy between 1996 and 2000 were enrolled on the study. Their parents provided proxy assessments of their health status at a maximum of 10 assessment points during therapy using the Comprehensive Health Status Classification System for Pre\u2010school Children (CHSCS\u2010PS), which assesses level of function on 10 separate health domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010six assessment questionnaires were completed. Maximum morbidity was reported immediately following diagnosis and in the 2\u20133 weeks following bone marrow transplantation. The greatest morbidity was observed in the pain, self\u2010care, mobility, and emotion domains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In addition to facing a high risk of mortality, young children being treated for advanced neuroblastoma also experience considerable morbidity. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20133","type":"journal-article","created":{"date-parts":[[2004,7,7]],"date-time":"2004-07-07T22:04:06Z","timestamp":1089237846000},"page":"659-667","source":"Crossref","is-referenced-by-count":11,"title":["Health status of young children during therapy for advanced neuroblastoma"],"prefix":"10.1002","volume":"43","author":[{"given":"P.C.","family":"Nathan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Furlong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"De Pauw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Horsman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Van Schaik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rolland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Weitzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Feeny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.D.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,7]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"761","volume-title":"Principles and practice of pediatric oncology","author":"Brodeur GM","year":"1997"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1425"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00366-9"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.18.3280"},{"key":"e_1_2_6_6_2","first-page":"284","article-title":"An assessment of global health status in survivors of leukemia in childhood","volume":"15","author":"Barr RD","year":"1993","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_6_7_2","unstructured":"SaigalS RosenbaumP FeenyD et al.Multi\u2010attribute health status classification system for pre\u2010school children: Final Report to The Medical Council of Canada for Grant No. MA 12956. 2000. 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