{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:32:00Z","timestamp":1787934720217,"version":"build-2784847793"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T00:00:00Z","timestamp":1100563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Histiocytic disorders are currently identified by their component cells. The non\u2010Langerhans Cell Histiocytoses (non\u2010LCH) are a group of disorders defined by the accumulation of histiocytes that do not meet the phenotypic criteria for the diagnosis of Langerhans cells (LCs). The non\u2010LCH consist of a long list of diverse disorders which have been difficult to categorize. A conceptual way to think of these disorders that make them less confusing and easier to remember is proposed based on immunophenotyping and clinical presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinically the non\u2010LCH can be divided into 3 groups, those that predominantly affect skin, those that affect skin but have a major systemic component, and those that primarily involve extracutaneous sites, although skin may be involved. Immunohistochernically many of the non\u2010LCH appear to arise from the same precursor cell namely the dermal dendrocyte. Juvenile Xanthogranuloma (JXG) is the model of the dermal dendrocyte\u2010derived non\u2010LCH. Other non\u2010LCH with differing clinical presentation and occurring at different ages but with an identical immunophenotype appear to form a spectrum of the same disorder, deriving from the same precursor cell at different stages of maturation. They should be considered as members of a JXG family. Non\u2010JXG family members include Sinus histiocytosis with massive lymphadenopathy (Rosai\u2010Dorfman disease).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The non\u2010LCH can be classified as JXG family and non\u2010JXG family and subdivided according to fairly clear\u2010cut clinical criteria. Utilization of this type of approach will allow better categorization, easier review of the literature and more accurate therapy decision\u2010making. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20246","type":"journal-article","created":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T04:50:32Z","timestamp":1100667032000},"page":"256-264","source":"Crossref","is-referenced-by-count":250,"title":["Uncommon histiocytic disorders: The non\u2010Langerhans cell histiocytoses"],"prefix":"10.1002","volume":"45","author":[{"given":"Sheila","family":"Weitzman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,16]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"63","volume-title":"Dendritic cells: biology and clinical application","author":"Caux C","year":"1999"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2003.11107805.x"},{"key":"e_1_2_9_4_2","first-page":"77","article-title":"The cutaneous \u201chistiocytoses\u201d","volume":"17","author":"Zelger BWH","year":"2001","journal-title":"Adv Dermatol"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/0470871628.ch17"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199610000-00008"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2000.03821.x"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199709)29:3<157::AID-MPO1>3.0.CO;2-C"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04367.x"},{"key":"e_1_2_9_10_2","first-page":"222","article-title":"Adult Langerhans cell histiocytosis\u2014A review of 46 cases","volume":"38","author":"Munn S","year":"2001","journal-title":"Med Pediatr Oncol"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00362.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(99)80017-0"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb03590.x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199308000-00004"},{"key":"e_1_2_9_15_2","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1365-2133.2000.03723.x","article-title":"Progressive nodular histiocytosis accompanied by systemic disorders","volume":"143","author":"Gonzalez\u2010Ruiz A","year":"2000","journal-title":"Br J Dermatol"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200305000-00003"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01842.x"},{"key":"e_1_2_9_18_2","first-page":"99","article-title":"Non\u2010Langerhans dendritic cell histiocytosis (abstract)","volume":"5","author":"Jaffe R","year":"2002","journal-title":"Pediatr Dev Pathol"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.00989.x"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70247-0"},{"key":"e_1_2_9_21_2","first-page":"1057","article-title":"Juvenile Xanthogranuloma. 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