{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:43:04Z","timestamp":1789645384277,"version":"4.0.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,2,7]],"date-time":"2005-02-07T00:00:00Z","timestamp":1107734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transient hyperglycemia occurs commonly during the treatment for childhood acute lymphoblastic leukemia (ALL). The purpose of this study was to examine the incidence of and risk factors for transient hyperglycemia during induction chemotherapy in Hispanic pediatric patients diagnosed with B\u2010Precursor ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The study cohort consisted of 155 Hispanic pediatric patients diagnosed with ALL and treated at one of two South Texas pediatric oncology centers between 1993 and 2002. Hyperglycemia was defined as \u22652 glucose determinations of \u2265200 mg\/dl during the first 28 days of induction chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 11.0% of the study cohort developed transient hyperglycemia during induction chemotherapy. Age and body mass index (BMI) were both positively associated with the risk of hyperglycemia. Females exhibited a substantially higher risk of hyperglycemia than males, but this association did not reach statistical significance after adjusting for other covariates. Among patients who developed hyperglycemia, 100% of those who required insulin were in the 13\u201318\u2010year age group and reported a family history of diabetes. Hyperglycemic patients classified as obese (BMI \u226595 centile) were more than twice as likely to have required insulin therapy compared to overweight patients (BMI 85\u2013&lt;95 centile) and three times as likely to have required insulin compared to normal weight (BMI &lt;85 centile) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of chemotherapy\u2010induced transient hyperglycemia in the present study cohort is comparable to that reported in previous pediatric ALL patients. This finding is interesting in view of the elevated prevalence of obesity and the underlying dietary behaviors in this Hispanic study cohort. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20320","type":"journal-article","created":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T07:17:05Z","timestamp":1107847025000},"page":"960-963","source":"Crossref","is-referenced-by-count":46,"title":["Transient hyperglycemia in Hispanic children with acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"45","author":[{"given":"Jacques","family":"Baillargeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Langevin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Mullins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert J.","family":"Ferry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"DeAngulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Pitney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad H.","family":"Pollock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(02)00042-5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20071"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80955-9"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.4.701"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.8.837"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1728"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1200\/JCO.1996.14.1.4","article-title":"Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia","volume":"14","author":"Smith M","year":"1996","journal-title":"J Clin Oncol"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.3.671"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.12.4591"},{"key":"e_1_2_7_11_2","volume-title":"Weight\u2010stature indices to measure underweight, overweight, and obesity","author":"Cole T","year":"1991"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/59.2.307"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.22.2845"},{"key":"e_1_2_7_14_2","first-page":"50","article-title":"Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease","author":"Burghen G","year":"1980","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00548767"},{"key":"e_1_2_7_16_2","first-page":"1372","article-title":"Diabetogenic effect of l\u2010asparaginase","volume":"29","author":"Khan A","year":"1969","journal-title":"J Clinl Endocrinol Metab"},{"key":"e_1_2_7_17_2","first-page":"406","article-title":"Low\u2010dosage asparaginase treatment of childhood acute lymphocytic leukemia","volume":"121","author":"Pratt C","year":"1971","journal-title":"Am J Dis Child"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-2-277"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8727(96)00046-3"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198607243150402"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.14.2.102"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.8.3051"}],"container-title":["Pediatric Blood &amp; 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