{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:58:45Z","timestamp":1790117925652,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,7]],"date-time":"2005-02-07T00:00:00Z","timestamp":1107734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Osteopathy is one of the common initial symptoms of acute lymphocytic leukemia (ALL) in children and adolescents, but multiple osteolysis accompanied by hypercalcemia is rarely observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We treated a 14\u2010year\u2010old female who had multiple osteolytic lesions and hypercalcemia at initial onset of ALL. In this case we examined some humoral factors, which are known to associate with hypercalcemia in malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Parathyroid hormone\u2010related peptide (PTHrP) was elevated in serum, and reverse transcriptase\u2010polymerase chain reaction and immunohistochemistry revealed that the lymphoblasts produced PTHrP directly. Other humoral factors related to hypercalcemia were not detected. ALL relapsed in the bone marrow 3 months after achieving complete remission, and hypercalcemia and elevation of serum PTHrP were also observed. A second remission could not be achieved and hypercalcemia continued. The patient received allogeneic bone marrow transplantation. The serum calcium level became normal after the conditioning therapy. Before engraftment, however, the patient died of infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present case suggests that blast\u2010producing PTHrP might be associated with multiple osteolytic lesions and hypercalcemia. PTHrP expressed in the lymphoblasts may, in itself, confer a survival advantage to lymphoblasts and contribute to the refractory nature of the disease. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20357","type":"journal-article","created":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T04:16:41Z","timestamp":1107836201000},"page":"333-339","source":"Crossref","is-referenced-by-count":41,"title":["Acute lymphocytic leukemia in adolescence with multiple osteolytic lesions and hypercalcemia mediated by lymphoblast\u2010producing parathyroid hormone\u2010related peptide: A case report and review of the literature"],"prefix":"10.1002","volume":"45","author":[{"given":"Hidemi","family":"Shimonodan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Nagayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Nagatoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiki","family":"Hatanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,7]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"489","volume-title":"Principles and practices of pediatric oncology","author":"Margolin JF","year":"2002"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.69.812.483"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198406283102607"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198809013190906"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8 <1564::AID-CNCR6>3.0.CO;2-K"},{"key":"e_1_2_4_7_2","first-page":"357","article-title":"Hypercalcemia in a case of childhood acute lymphoblastic leukemia","volume":"17","author":"Todo S","year":"1987","journal-title":"Jpn J Clin Oncol"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02787346"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.2.671"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.2.634"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-9883"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00869834"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.4.990"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199802)30:2<117::AID-MPO9>3.0.CO;2-L"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200402000-00011"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930215)71:4<1309::AID-CNCR2820710423>3.0.CO;2-M"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199809050909"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770100305"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870315)59:6<1187::AID-CNCR2820590626>3.0.CO;2-8"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930701)72:1<256::AID-CNCR2820720145>3.0.CO;2-D"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841115)54:10<2132::AID-CNCR2820541013>3.0.CO;2-V"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91139-1"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92864-8"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-5-2600"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040106"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11924"},{"key":"e_1_2_4_27_2","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040314"},{"key":"e_1_2_4_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-125-1-20"},{"key":"e_1_2_4_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.3.759"},{"key":"e_1_2_4_30_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1390323"},{"key":"e_1_2_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-5710(97)00052-2"},{"key":"e_1_2_4_32_2","first-page":"1708","article-title":"Increased serum levels of C\u2010terminal parathyroid hormone\u2010related protein in different diseases associated with HTLV\u20101 infection","volume":"8","author":"Yamaguchi K","year":"1994","journal-title":"Leukemia"},{"key":"e_1_2_4_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.2.6573"},{"key":"e_1_2_4_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02388764"},{"key":"e_1_2_4_35_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199609054810"},{"key":"e_1_2_4_36_2","first-page":"126","article-title":"Bone involvement in childhood acute lymphoblastic leukaemia","volume":"73","author":"Wessels G","year":"1996","journal-title":"East Afr Med J"},{"key":"e_1_2_4_37_2","first-page":"171","article-title":"A case of acute lymphoblastic leukemia accompanied with the production of parathyroid hormone\u2010related protein","volume":"21","author":"Harutsumi M","year":"1995","journal-title":"Miner Electrolyte Metab"},{"key":"e_1_2_4_38_2","first-page":"6015","article-title":"Parathyroid hormone\u2010related protein as a growth regulator of prostate carcinoma","volume":"59","author":"Dougherty KM","year":"1999","journal-title":"Cancer Res"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20357","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T09:40:28Z","timestamp":1697103628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,7]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1002\/pbc.20357"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20357","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,7]]}}}