{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:55:27Z","timestamp":1760244927321},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,4,25]],"date-time":"2005-04-25T00:00:00Z","timestamp":1114387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaplastic lymphoma kinase (ALK) positive diffuse large B\u2010cell lymphoma (DLBCL) is a rare subtype of non\u2010Hodgkins lymphoma. Five such cases have been described in children. We present a 9\u2010year\u2010old boy, in whom diagnosis of DLBCL has been established in addition to congenital multiple enchondromatosis. Immunohistopathological evaluation of tumor biopsy established the final diagnosis of ALK\u2009+\u2009DLBCL. The clathrin gene (<jats:italic>CLTC<\/jats:italic>)\u2010ALK fusion underlying aberrant expression of ALK in the present case was demonstrated by interphase fluorescence in situ hybridization (FISH) using break\u2010apart rearrangement probes for ALK and <jats:italic>CLTC<\/jats:italic>. The disease in this patient was highly resistant to applied chemotherapy regimens and to radiotherapy. Analysis of the disease course in our patient and review of other cases reported previously show that ALK\u2009+\u2009DLBCL can be an aggressive malignancy that can be cured with conventional chemotherapy protocols only at stage of localized disease. Pediatr Blood Cancer \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20396","type":"journal-article","created":{"date-parts":[[2005,4,25]],"date-time":"2005-04-25T18:22:53Z","timestamp":1114453373000},"page":"649-653","source":"Crossref","is-referenced-by-count":23,"title":["ALK\u2010positive diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"46","author":[{"given":"Halina","family":"Buba\u0142a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Ma\u0142dyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"W\u0142odarska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danuta","family":"So\u0144ta\u2010Jakimczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Szczepa\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605093341906"},{"key":"e_1_2_6_3_2","first-page":"416","article-title":"Intensive ALL\u2010type therapy without local radiotherapy provides a 90% event\u2010free survival for children with T\u2010cell lymphoblastic lymphoma: A BFM group report","volume":"95","author":"Reiter A","year":"2000","journal-title":"Blood"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3370"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.12.3699"},{"key":"e_1_2_6_6_2","volume-title":"World Health Organization classification of tumours. 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