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We describe a 4\u2010week\u2010old neonate with <jats:italic>MYCN<\/jats:italic>\u2010amplified stage 4S NB complicated by gross hepatomegaly causing rapidly progressive respiratory, hepatic, and renal failure. The child remains in remission 3 years after hepatic artery embolization, radiotherapy, standard, and high\u2010dose chemotherapy. Embolization of the hepatic artery, with classical treatment, is feasible and safe at this age and may contribute substantially to the management of high\u2010risk patients. Pediatr Blood Cancer \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20407","type":"journal-article","created":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T10:54:18Z","timestamp":1117536858000},"page":"253-257","source":"Crossref","is-referenced-by-count":18,"title":["Successful treatment of <i>MYCN<\/i> amplified, progressive stage 4S neuroblastoma in a neonate with hepatic artery embolization in addition to multimodality treatment"],"prefix":"10.1002","volume":"46","author":[{"given":"Kaan","family":"Boztug","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Kiely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek J.","family":"Roebuck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Gaze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Begent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penelope","family":"Brock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antony","family":"Michalski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,20]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1014"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.6.2007"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.8.1466"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91606-0"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.3.477"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920915)70:6<1625::AID-CNCR2820700631>3.0.CO;2-6"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199612)27:6<521::AID-MPO3>3.0.CO;2-N"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970901)80:5<834::AID-CNCR2>3.0.CO;2-L"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20080"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910143411601"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20067"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92834-7"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880815)62:4<818::AID-CNCR2820620430>3.0.CO;2-K"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950130504"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/088800199277010"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200202000-00017"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005778607661"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(95)00044-J"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(03)00103-4"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-1051-2"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)00237-2"},{"key":"e_1_2_4_23_2","first-page":"969","article-title":"Blood supply of neoplasms in the liver","volume":"30","author":"Breedis C","year":"1954","journal-title":"Am J Pathol"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.140.1.7244243"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00069-0"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i2.193"},{"key":"e_1_2_4_27_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.6.1279"},{"key":"e_1_2_4_28_2","doi-asserted-by":"publisher","DOI":"10.3816\/CCC.2002.n.022"},{"key":"e_1_2_4_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19941101)74:9<2449::AID-CNCR2820740910>3.0.CO;2-4"}],"container-title":["Pediatric Blood &amp; 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