{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:22:07Z","timestamp":1774714927667,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,7,8]],"date-time":"2005-07-08T00:00:00Z","timestamp":1120780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Disseminated lymphangiomatosis is a rare disease mostly observed in children and young adults. If no surgical removal can be achieved, the prognosis is poor, especially for patients with thoracic localization and pleural effusions. Next to pleural drainage, therapeutic options include radiotherapy, local, and systemic pharmacotherapy. An 11\u2010year\u2010old boy presented with disseminated lymphangiomatosis involving thorax with massive pleural effusions, retroperitoneum, and bones. In immunohistochemical analysis, the tissue biopsy stained positive for vascular endothelial growth factor\u2010receptor 3 (VEGFR\u20103). The patient has been treated with interferon alpha 2b for 2 years, and achieved a good clinical and radiological response. Pediatr Blood Cancer 2007;48:108\u2013111. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20461","type":"journal-article","created":{"date-parts":[[2005,7,8]],"date-time":"2005-07-08T20:08:25Z","timestamp":1120853305000},"page":"108-111","source":"Crossref","is-referenced-by-count":27,"title":["Interferon alpha 2b treatment in an eleven\u2010year\u2010old boy with disseminated lymphangiomatosis"],"prefix":"10.1002","volume":"48","author":[{"given":"Christian","family":"Timke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin F.","family":"Krause","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Conrad","family":"Oppermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Leuschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Claviez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,7,8]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.3.9904056"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.83.2.138"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90694-6"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199205283262203"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199705000-00011"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.2.556"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90265-I"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/107710496176001"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199705000-00010"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70412-3"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(200004)29:4<321::AID-PPUL13>3.0.CO;2-C"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(02)00117-9"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.06.081"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000080748"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70034-4"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200407000-00017"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20461","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T13:18:24Z","timestamp":1700054304000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,8]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1002\/pbc.20461"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20461","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,8]]}}}