{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T10:43:17Z","timestamp":1753180997151},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T00:00:00Z","timestamp":1128297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The outcome for patients presenting with acute renal failure and Burkitt lymphoma (BLARF) without dialysis is poor. This was a retrospective non\u2010randomized comparative study designed to determine the outcome of two different treatment protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One group of patients (TPA) received oral allopurinol, intravenous (IV) cyclophosphamide, vincristine, methotrexate, furosemide, 8.4% sodium bicarbonate, and intrathecal (IT) methotrexate; the other (TPB) alternate day IV infusion of low dose cyclosphosphamide (125 mg\/m<jats:sup>2<\/jats:sup>\u2009\u00d7\u20094 doses), IT methotrexate (Days 1 and 5) and aggressive pre\u2010emptive anti\u2010tumor lysis syndrome therapy including oral allopurinol and calcium lactate, IV calcium gluconate, salbutamol, insulin and infusions of furosemide, sodium bicarbonate and glucose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine of 16 received TPA, 7 received TPB. Post chemotherapy anemia was more severe with TPA (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). TPB patients received significantly more chemotherapy than those in TPA (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). All 16 had tumor lysis syndrome (TLS). Six of nine patients with TPA died from this (three from other causes), two deaths in TPB were due to causes other than tumor lysis. Other evaluated outcome indices were similar in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Slow IV infusion of low dose cyclophosphamide given on alternate days in addition to pre\u2010emptive anti\u2010TLS measures (TPB) were associated with better outcome in BLARF patients compared to a high dose multiple chemotherapy regimen (TPA). Pediatr Blood Cancer 2006, 46:446\u2013453. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20473","type":"journal-article","created":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T21:19:03Z","timestamp":1128374343000},"page":"446-453","source":"Crossref","is-referenced-by-count":8,"title":["Acute renal failure in African children with Burkitt's lymphoma: A comparison of two treatment regimens"],"prefix":"10.1002","volume":"46","author":[{"given":"Wasiu A.","family":"Olowu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome B.E.","family":"Elusiyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sekinat A.","family":"Badejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olusola A.","family":"Adenowo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,3]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"500p","volume-title":"International incidence of childhood cancer, volume II (IARC Scientific Publications No. 144)","author":"Parking DM","year":"1998"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197707142970202"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/02724936.1997.11747882","article-title":"Hypertension and acute renal failure in Nigerian children with Burkitt's lymphoma: Report of three cases and review","volume":"17","author":"Olowu WA","year":"1997","journal-title":"Ann Trop Paediatr"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91223-3"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00918.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1255-5"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36251-4"},{"key":"e_1_2_5_9_2","first-page":"129","article-title":"Treatment of Burkitt's lymphoma","volume":"4","author":"Ziegler JL","year":"1974","journal-title":"Pathobiol Annu"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.79.1.1","article-title":"Report of the Second Task Force on blood pressure control in children","volume":"79","author":"National Heart, Lung and Blood Institute","year":"1987","journal-title":"Paediatrics"},{"key":"e_1_2_5_11_2","first-page":"173p","volume-title":"Essentials of medical statistics","author":"Kirkwood BR","year":"1988"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90597-5"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1542\/peds.82.6.863","article-title":"Acute renal failure at onset of therapy for advanced stage Burkitt's lymphoma and B cell acute lymphoblastic lymphoma","volume":"82","author":"Stapleton FB","year":"1988","journal-title":"Paediatrics"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197612)38:6<2588::AID-CNCR2820380653>3.0.CO;2-W"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860801)58:3<748::AID-CNCR2820580323>3.0.CO;2-U"},{"key":"e_1_2_5_16_2","first-page":"531","article-title":"Acute renal failure in 11 children with non\u2010Hodgkin lymphoma","volume":"18","author":"Radaelli L","year":"1981","journal-title":"Proc Eur Dial Transpl Assoc"},{"key":"e_1_2_5_17_2","first-page":"F423","article-title":"A proposed role for adenosine in the regulation of renal haemodynamics and renin release","volume":"242","author":"Spielman WS","year":"1982","journal-title":"Am J Physiol Soc"},{"key":"e_1_2_5_18_2","first-page":"14","article-title":"Burkitt's lymphoma in a Nigerian population","volume":"4","author":"Onwukeme KE","year":"1995","journal-title":"Nig J Med"},{"key":"e_1_2_5_19_2","first-page":"317","article-title":"Burkitt's lymphoma\u2014A model for intensive chemotherapy","volume":"4","author":"Ziegler JL","year":"1977","journal-title":"Semin Oncol"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00860936"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.135.2.307"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.70.2.126"},{"key":"e_1_2_5_23_2","first-page":"197","volume-title":"Clinical paediatric nephrology","author":"Arbus GS","year":"1986"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90286-7"},{"key":"e_1_2_5_25_2","first-page":"305","article-title":"Acute renal failure in children requiring dialysis therapy","volume":"31","author":"Kandoth PW","year":"1994","journal-title":"Indian Paediatr"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20473","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T07:11:34Z","timestamp":1696662694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,3]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1002\/pbc.20473"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20473","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,3]]}}}