{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:38:46Z","timestamp":1780429126557,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Children born without a spleen or who have impaired splenic function, due to disease or splenectomy, are at significantly increased risk of life\u2010threatening bacterial sepsis. The mainstays of prevention are education, immunization, and prophylactic antibiotics. The availability of conjugate 7\u2010valent pneumococcal vaccines for use in children to age 9 years at least, as well as conjugate meningococcal C vaccine in some countries, for use beginning in infancy, appear to represent beneficial additions, but not substitutions, to previous recommendations for the use of polysaccharide 23\u2010valent pneumococcal and quadrivalent A, C, Y, W\u2010135 vaccines. Routine immunization against <jats:italic>H. influenzae<\/jats:italic> type b should continue with non\u2010immunized children older than age 5 years receiving two doses 2 months apart, similar to children who have not previously received conjugate pneumococcal vaccine in infancy. Annual influenza immunization, which reduces the risk of secondary bacterial infection, is also recommended for asplenic children and their household contacts. Many experts continue prophylaxis indefinitely although prophylaxis of the penicillin allergic child remains suboptimal. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20477","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T20:49:30Z","timestamp":1133902170000},"page":"597-603","source":"Crossref","is-referenced-by-count":57,"title":["The prevention and treatment of bacterial infections in children with asplenia or hyposplenia: Practice considerations at the Hospital for Sick Children, Toronto"],"prefix":"10.1002","volume":"46","author":[{"given":"Victoria E.","family":"Price","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor S.","family":"Blanchette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Butchart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Kirby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob C.","family":"Langer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Lee","family":"Ford\u2010Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_12_2_2","first-page":"307","volume-title":"Clinical management of infections in immunecompromised infants and children","author":"Chesney JA","year":"2001"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(92)90021-Q"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198202000-00009"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)01407-1"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199904000-00050"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.1.194-a"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-6-461"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70322-6"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.181.4.1811021"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70225-5"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1980.01380060070021"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100240010145"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70159-8"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00144007"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90298-5"},{"key":"e_1_2_12_17_2","first-page":"285","article-title":"Postsplenectomy sepsis","volume":"1","author":"Singer DB","year":"1973","journal-title":"Perspect Pediatr Pathol"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800780904"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1198-743x.2001.00355.x"},{"key":"e_1_2_12_20_2","volume-title":"Immunocompromised children\u2014Asplenic children. The red book, report of the committee on infectious diseases","author":"American Academy of Pediatrics","year":"2000"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050550"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.2.362"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01740820"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606193142501"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(99)90565-1"},{"key":"e_1_2_12_26_2","first-page":"705","volume-title":"Moffet's pediatric infectious diseases\u2014A problem oriented approach","author":"Fisher Randall G","year":"2005"},{"key":"e_1_2_12_27_2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/pch\/4.6.417","article-title":"Prevention and therapy of bacterial infections for children with asplenia or hyposplenia","volume":"4","author":"Infectious Diseases and Immunization Committee, Canadian Paediatric Society","year":"1999","journal-title":"Paediatr Child Health"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.2-5-440"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1999.01373.x"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199707000-00011"},{"key":"e_1_2_12_31_2","unstructured":"Centers for Diseases Control.2003.Epidemiology and prevention of vaccine preventable diseases. The pink book 7th ed.http:\/\/www.cdc.gov\/nip\/publications\/pink\/"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199805000-00004"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268897007978"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200212000-00001"},{"key":"e_1_2_12_35_2","first-page":"1","article-title":"Prevention of pneumococcal disease","volume":"46","author":"Advisory committee on Immunisation Practices (ACIP)","year":"1997","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.5.1210"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2003.00158.x"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.332-337.2004"},{"key":"e_1_2_12_39_2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/pch\/9.8.567","article-title":"Varicella (chickenpox)","volume":"9","author":"Tan B","year":"2004","journal-title":"Paediatr Child Health"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20477","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:49:06Z","timestamp":1697086146000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,6]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1002\/pbc.20477"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20477","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,6]]}}}