{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:33:11Z","timestamp":1760297591274},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T00:00:00Z","timestamp":1137542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study is a pilot experience aiming to investigate the compliance of an institutional cohort of Italian children treated for a malignant disease and their families in completing the health utilities index2, (HUI2) and the effectiveness of this measured in terms of their health status (HS) and health\u2010related quality of life (HRQL). It specifically, it aimed to compare the HS and the HRQL, as expressed by the HUI2 global utility score, in cohorts of patients who had brain tumors, extra\u2010cerebral solid tumors, or leukemia\/lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Fifty survivors of brain tumors, between 8 and 30 years at the time of the assessment (\u201cself\u201d) and\/or their parents (\u201cproxy\u201d), attending the Pediatric Oncology Out Patient clinic of Padua, Italy, completed the HUI2 questionnaire. Eighty\u2010nine children with acute leukemia\/lymphoma and 74 with extra\u2010cerebral solid tumors and\/or their parents were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean \u201cself\u201d and \u201cproxy\u201d HUI2 global utility scores in the brain tumor patients were 0.87 and 0.84, respectively, while in the cohorts of children with other solid tumors and leukemia\/lymphoma, there were 0.94, 0.91, 0.96, and 0.92, respectively. The differences between the HUI2 global utility scores in the \u201cself\u201d and \u201cproxy\u201d assessment within each cohort of children were not statistically significant. In decreasing order of frequency, the attributes affected most commonly were: \u201c<jats:italic>emotion<\/jats:italic>,\u201d \u201c<jats:italic>pain<\/jats:italic>,\u201d \u201c<jats:italic>sensation<\/jats:italic>,\u201d and \u201c<jats:italic>cognition<\/jats:italic>\u201d both by \u201cself\u201d and \u201cproxy\u201d assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this Italian population of childhood cancer survivors the HUI2 questionnaire proved to be a user\u2010friendly tool, which provided information regarding HS and HRQL. A larger cohort of cancer children is needed to confirm the efficacy of the HUI2 questionnaire in distinguishing groups of children on this basis by disease category. Pediatric Blood Cancer \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20480","type":"journal-article","created":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T21:57:04Z","timestamp":1137621424000},"page":"637-644","source":"Crossref","is-referenced-by-count":36,"title":["Evaluation of health status and health\u2010related quality of life in a cohort of Italian children following treatment for a primary brain tumor"],"prefix":"10.1002","volume":"46","author":[{"given":"Chiara","family":"Cardarelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Cereda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Masiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Viscardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Faggin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AnnaMaria","family":"Laverda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Bisogno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Perilongo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011115)92:10<2709::AID-CNCR1625>3.0.CO;2-D"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.202"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1227\/00006123-198711000-00006","article-title":"Factors affecting intellectual outcome in pediatric brain tumor patients","volume":"21","author":"Ellenberg L","year":"1987","journal-title":"Neurosurg"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000120325"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00165522"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/23.5.279"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200111000-00005"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2214.2003.00318.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(1999)83:12 <77::AID-IJC14>3.0.CO;2-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(1999)83:12 <25::AID-IJC6>3.0.CO;2-Q"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(1999)83:12 <112::AID-IJC20>3.0.CO;2-J"},{"key":"e_1_2_6_13_2","first-page":"1327","volume-title":"Cancer medicine, vol.1","author":"Holland JC","year":"1999"},{"key":"e_1_2_6_14_2","first-page":"191","volume-title":"Evaluation of chemotherapeutic agents","author":"Karnofsky DA","year":"1949"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970715)80:2<258::AID-CNCR14>3.0.CO;2-T"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(1999)83:12 <106::AID-IJC19>3.0.CO;2-T"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(96)00024-X"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)04205-0"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00761"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00439227"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1037\/0278-6133.12.3.246","article-title":"An investigation of the validity of the quality of well being scale with pediatric oncology patients","volume":"12","author":"Bradlyn AS","year":"1993","journal-title":"Health Psychol"},{"key":"e_1_2_6_22_2","first-page":"309","volume-title":"Quality of life and pharmacoeconomics in clinical trials","author":"Kaplan RM","year":"1996"},{"key":"e_1_2_6_23_2","unstructured":"LandgrafJM AbetzL WareJE.Child health questionnaire (CHQ): A user's manual. 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