{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:05:16Z","timestamp":1760249116019},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,7,26]],"date-time":"2005-07-26T00:00:00Z","timestamp":1122336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies on cardiac function in patients with sickle cell disease (SCD) demonstrated abnormalities of systolic and diastolic function including elevated left ventricular myocardial performance index (LVMPI) on chronic transfusion protocols. LVMPI has been validated as a useful and easy non\u2010invasive measure of overall cardiac function. Up to now, there are no reported studies on cardiac function in patients with SCD maintained on long\u2010term erythrocytapheresis (LTE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>We recorded LVMPI in 22 patients with SCD aged 3\u201320 years and we compared the results between non\u2010transfused patients (NT\u2010SCD) and patients on LTE (T\u2010SCD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Males with SCD had higher mean LVMPI than females (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). There were significant differences among T\u2010SCD, severe NT\u2010SCD, and mild NT\u2010SCD patients with respect to hemoglobin (Hb) levels (<jats:italic>P<\/jats:italic>\u2009=\u2009.003) and TR velocity (<jats:italic>P<\/jats:italic>\u2009=\u2009.03). T\u2010SCD patients showed elevated LVMPI compared to NT\u2010SCD patients with severe and mild disease (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). Pair\u2010wise comparisons demonstrated that T\u2010SCD patients had LVMPI that was significantly higher than NT\u2010SCD (mild) patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrates that patients SCD on LTE have cardiac dysfunction based on elevated LVMPI. This may be a reflection of the global severity of disease. Our findings merit further investigation with serial monitoring of LVMPI on a larger number of patients with SCD. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20521","type":"journal-article","created":{"date-parts":[[2005,7,26]],"date-time":"2005-07-26T21:16:52Z","timestamp":1122412612000},"page":"976-981","source":"Crossref","is-referenced-by-count":14,"title":["Quantitative assessment of ventricular function in sickle cell disease: Effect of long\u2010term erythrocytapheresis"],"prefix":"10.1002","volume":"45","author":[{"given":"Ashok B.","family":"Raj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Condurache","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Bertolone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Sobczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,7,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.5.1214"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-002-1469-5"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00021001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(97)70090-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10154"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200405000-00004"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200210000-00009"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035477"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01047-X"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01222-4"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(99)70102-1"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-002-0017-7"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.02.002"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)00660-5"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.07.009"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-003-1275-y"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.1999.01155.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200312000-00015"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.2.e183"},{"key":"e_1_2_6_22_2","first-page":"6","article-title":"Autopsy findings in sickle cell disease","volume":"51","author":"Escoffery CT","year":"2000","journal-title":"Jacksonville Medicine"},{"key":"e_1_2_6_23_2","first-page":"507","article-title":"Sickle cells and sudden death: Morphologic abnormalities of the cardiac conduction system","volume":"124","author":"James TN","year":"1994","journal-title":"J Lab Clin Med"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92087-0"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20521","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T11:28:04Z","timestamp":1697628484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,26]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1002\/pbc.20521"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20521","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,26]]}}}