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We prescribed cyclophosphamide after failure of corticosteroids. Cyclophosphamide induced a fast regression of the lesions with no side effects in both infants. We were able to stop treatment after 3\u20134 courses of cyclophosphamide in both infants because of the excellent response. Cyclophosphamide seems to be a safe and effective treatment in patients suffering from life\u2010threatening DNH unresponsive to corticosteroids. Pediatr Blood Cancer 2006;46:239\u2013242. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20522","type":"journal-article","created":{"date-parts":[[2005,12,20]],"date-time":"2005-12-20T18:18:58Z","timestamp":1135102738000},"page":"239-242","source":"Crossref","is-referenced-by-count":35,"title":["Two infants with life\u2010threatening diffuse neonatal hemangiomatosis treated with cyclophosphamide"],"prefix":"10.1002","volume":"46","author":[{"given":"Sven","family":"Gottschling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Reinhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dill\u2010Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Graf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.85.4.491"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.58.2.218"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200011000-00012"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70065-3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1986.tb00506.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21411.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(07)80004-1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198004103021508"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(85)80283-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197102)27:2<364::AID-CNCR2820270219>3.0.CO;2-V"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.156.1.4001425"},{"key":"e_1_2_6_13_2","first-page":"745","article-title":"Successful treatment of a giant cavernous hemangioma with oral cyclophosphamide (cytoxan) in an infant","volume":"64","author":"Castro R","year":"1992","journal-title":"Del Med J"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196708172770703"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2003.10.014"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199205283262203"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80405-X"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(82)80332-1"},{"key":"e_1_2_6_19_2","first-page":"875","article-title":"Successful treatment with cyclophosphamide in a large hepatic hemangioendothelioma","volume":"31","author":"Manglani M","year":"1994","journal-title":"Indian Pediatr"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90694-6"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507063330120"},{"key":"e_1_2_6_22_2","first-page":"571","article-title":"Hepatic hemangioma in the neonate: Description of a case treated surgically with favorable outcome","volume":"4","author":"Schiavon G","year":"1982","journal-title":"Pediatr Med Chir"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992288302200817"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(81)80572-6"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70034-4"},{"key":"e_1_2_6_26_2","first-page":"1092","volume-title":"Principles and practise of pediatric oncology","author":"Pizzo PA","year":"1993"}],"container-title":["Pediatric Blood &amp; 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