{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:43:07Z","timestamp":1782481387316,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,8,5]],"date-time":"2005-08-05T00:00:00Z","timestamp":1123200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the safety of delayed high dose intravenous (i.v.) sodium thiosulfate (STS) in a case series of 12 children with malignant brain tumors who were treated with intraarterial (i.a.) carboplatin in conjunction with blood\u2010brain\u2010barrier disruption (BBBD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve children ages 17 months\u201312 years underwent a total of 132 BBBD chemotherapy treatments and also received delayed high dose STS (i.v.). Dose 1 of STS (10\u201316 g\/m<jats:sup>2<\/jats:sup>) was administered 2 or 4 hr after carboplatin, and a second STS dose was administered 4 hr after dose 1 if the child had impaired baseline hearing. Toxicity data were graded in accordance with the National Cancer Institute Common Toxicity Criteria (Version 2). Audiologic monitoring to evaluate the otoprotective potential of STS was performed on 11 children. Ototoxicity was defined in accordance with the American Speech\u2010Language\u2010Hearing Association (ASHA) criteria. Baseline and end of treatment hearing status were graded using Brock's criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nausea and vomiting were well controlled with anti\u2010emetics administered approximately 30 min prior to STS infusion. Analogous to results in adult patients, there was mild transient hypernatremia and a trend for improved protection from ototoxicity in children who received STS delayed to 4 hr post\u2010treatment versus 2 hr. Tumor responses were seen in heavily pre\u2010treated patients with relatively chemo\u2010resistant tumors, suggesting that STS did not protect the tumor from platinum cytotoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High dose STS is well tolerated in children under 12 years of age. Further studies of STS in children are warranted to assess otoprotection and the impact of STS on platinum mediated efficacy. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20529","type":"journal-article","created":{"date-parts":[[2005,8,5]],"date-time":"2005-08-05T21:17:42Z","timestamp":1123276662000},"page":"174-182","source":"Crossref","is-referenced-by-count":45,"title":["Toxicity profile of delayed high dose sodium thiosulfate in children treated with carboplatin in conjunction with blood\u2010brain\u2010barrier disruption"],"prefix":"10.1002","volume":"47","author":[{"given":"Edward A.","family":"Neuwelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Gilmer\u2010Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Lacy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Stacy","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale F.","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy D.","family":"Doolittle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Hornig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie L.","family":"Muldoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,8,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(90)90151-E"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02897206"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2003.08.009"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701391"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950190415"},{"key":"e_1_2_7_7_2","first-page":"77","article-title":"First evidence of otoprotection against carboplatin\u2010induced hearing loss with a two\u2010compartment system in patients with central nervous system malignancy using sodium thiosulfate","volume":"286","author":"Neuwelt EA","year":"1998","journal-title":"J Pharmacol Exp Therap"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480020304"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(95)00066-D"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.087601"},{"key":"e_1_2_7_11_2","first-page":"309","article-title":"Delayed administration of sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity","volume":"6","author":"Muldoon LL","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_12_2","first-page":"706","article-title":"In vitro and animal studies of sodium thiosulfate as a potential chemoprotectant against carboplatin\u2010induced ototoxicity","volume":"56","author":"Neuwelt EA","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02905989"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900090094014"},{"key":"e_1_2_7_15_2","first-page":"493","article-title":"Delayed sodium thiosulfate as an otoprotectant against carboplatin\u2010induced hearing loss in patients with malignant brain tumors","volume":"7","author":"Doolittle ND","year":"2001","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000097715.11966.8E"},{"key":"e_1_2_7_17_2","first-page":"110","article-title":"The potential for complete and durable response in nonglial primary brain tumors in pediatric patients and young adults with enhanced chemotherapy delivery","volume":"4","author":"Dahlborg SA","year":"1998","journal-title":"Cancer J Sci Am"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01376517-199804000-00002"},{"key":"e_1_2_7_19_2","first-page":"11","article-title":"Guidelines for the audiologic management of individuals receiving cochleotoxic drug therapy","volume":"36","author":"ASHA","year":"1994","journal-title":"ASHA"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(83)90100-2"},{"key":"e_1_2_7_21_2","volume-title":"Hearing in children","author":"Northern JL","year":"1991"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(91)90081-F"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.063347"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199911000-00003"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200203000-00006"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20132"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20529","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T03:01:23Z","timestamp":1697166083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,5]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1002\/pbc.20529"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20529","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,5]]}}}