{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:38:41Z","timestamp":1770431921453,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T00:00:00Z","timestamp":1128297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present the unusual case of a 16\u2010year\u2010old girl with T\u2010cell acute lymphoblastic leukemia (ALL) with an early thymocyte immunophenotype without myeloid markers, who after 13 months of complete hematological remission relapsed as acute myelogenous leukemia (AML) with minimal differentiation and died of her disease. Whether the AML represented a relapse with lineage switch of the original immature T\u2010cell clone or a new secondary malignancy, could not be proven due to the absence of molecular or clonal markers. This report suggests that a subset of CD7+ T\u2010cell leukemias without mature T\u2010cell antigens (CD4\u2010, CD8\u2010) are minimally differentiated and can relapse as AML. Pediatr Blood Cancer 2007;48:354\u2013357. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20543","type":"journal-article","created":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T21:17:06Z","timestamp":1128374226000},"page":"354-357","source":"Crossref","is-referenced-by-count":14,"title":["T\u2010cell acute lymphoblastic leukemia relapsing as acute myelogenous leukemia"],"prefix":"10.1002","volume":"48","author":[{"given":"Elpis","family":"Mantadakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassiliki","family":"Danilatou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eftichia","family":"Stiakaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Paterakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanos","family":"Papadhimitriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kalmanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,3]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.8.2863"},{"key":"e_1_2_4_3_2","first-page":"735","article-title":"Biology and treatment of childhood T\u2010lineage acute lymphoblastic leukemia","volume":"91","author":"Uckun FM","year":"1998","journal-title":"Blood"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.3.1588"},{"key":"e_1_2_4_5_2","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias","volume":"9","author":"Bene MC","year":"1995","journal-title":"Leukemia"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.1.253"},{"key":"e_1_2_4_7_2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1182\/blood.V73.2.381.381","article-title":"CD7+, CD4\u2010, CD8\u2010 acute leukemia: A syndrome of malignant pluripotent lymphohematopoietic cells","volume":"73","author":"Kurtzberg J","year":"1989","journal-title":"Blood"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90167-S"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830400205"},{"key":"e_1_2_4_10_2","first-page":"1759","article-title":"Heterogeneity of CD7+4\u20101\u2010 leukemia: Usefulness of cytoplasmic antigen detection for subclassification","volume":"7","author":"Masuda M","year":"1993","journal-title":"Leukemia"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980201)82:3<488::AID-CNCR10>3.0.CO;2-Y"},{"key":"e_1_2_4_12_2","first-page":"196","article-title":"A case of T\u2010lineage lymphoblastic lymphoma\/ leukemia with t(4;11)(q21;p15) that switched to myelomonocytic leukemia at relapse","volume":"69","author":"Kawakami K","year":"1999","journal-title":"Int J Hematol"},{"key":"e_1_2_4_13_2","first-page":"877","article-title":"CD7(+) acute leukemia switching from a lymphoid to a myeloid phenotype","volume":"86","author":"Rossi M","year":"2001","journal-title":"Haematologica"},{"key":"e_1_2_4_14_2","first-page":"471","article-title":"T\u2010cell acute lymphoblastic leukemia occurring in a patient with acute promyelocytic leukemia","volume":"83","author":"Liso V","year":"1998","journal-title":"Haematologica"},{"key":"e_1_2_4_15_2","first-page":"1083","article-title":"Leukemic relapse as T\u2010acute lymphoblastic leukemia in a patient with acute myeloid leukemia and a minor T\u2010cell clone at diagnosis","volume":"85","author":"Bellido M","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(94)90185-6"},{"key":"e_1_2_4_17_2","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1182\/blood.V81.9.2399.2399","article-title":"Clinical importance of CD7 expression in acute myelocytic leukemia. The Japan Cooperative Group of Leukemia\/ Lymphoma","volume":"81","author":"Nakase K","year":"1993","journal-title":"Blood"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401067"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.2.470.470"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009054882"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(99)00223-X"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(01)00529-5"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000204815"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.5.1327.1327"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403327"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.2.209"},{"key":"e_1_2_4_27_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.2.569"},{"key":"e_1_2_4_28_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109057981"},{"key":"e_1_2_4_29_2","first-page":"258","article-title":"Diagnosis, classification, and cytogenetics of myelodysplastic syndromes","volume":"83","author":"Vallespi T","year":"1998","journal-title":"Haematologica"},{"key":"e_1_2_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(99)00142-9"},{"key":"e_1_2_4_31_2","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1182\/blood.V72.6.1891.1891","article-title":"Clinical features and outcome in childhood T\u2010cell leukemia\u2010lymphoma according to stage of thymocyte differentiation: A Pediatric Oncology Group Study","volume":"72","author":"Crist WM","year":"1988","journal-title":"Blood"},{"key":"e_1_2_4_32_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.6.2214"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20543","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T00:52:56Z","timestamp":1696726376000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1002\/pbc.20543"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20543","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,3]]}}}