{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:59:47Z","timestamp":1790809187706,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T00:00:00Z","timestamp":1125014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2005,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A significant number of studies describe the cytogenetics and molecular genetics of adult non\u2010Hodgkin lymphoma (NHL); however, similar knowledge is lacking regarding pediatric NHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A workshop to discuss the \u201cState of the Art and Future Needs in Cytogenetic\/Molecular Genetics\/Arrays\u201d in pediatric NHL was held in conjunction with the First International Symposium on Childhood and Adolescent Non\u2010Hodgkin Lymphoma on April 9, 2003 in New York City.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cytogenetic characteristics of pediatric NHL include 14q11.2 rearrangements in T\u2010cell lymphoblastic leukemia\/lymphomas (LBL), <jats:italic>ALK<\/jats:italic> rearrangements in anaplastic large cell lymphomas (ALCL), and <jats:italic>CMYC<\/jats:italic> translocations in both Burkitt and Burkitt\u2010like lymphomas (BL\/BLL). Pediatric diffuse large B\u2010cell lymphoma (DLBCL) is cytogenetically different from DLBCL in adults, suggesting a different disease in children. Microarray studies demonstrate three types of T\u2010cell leukemia, the leukemic counterpart of LBL, that block T\u2010cell differentiation at different stages of T\u2010cell development, corresponding to <jats:italic>LYL<\/jats:italic>, <jats:italic>TAL1<\/jats:italic>, and <jats:italic>HOX<\/jats:italic>\u2010expressing leukemias. ALCL cell lines have a unique expression profile compared to normal T\u2010cells. Germinal centers of BL have <jats:italic>CMYC<\/jats:italic> expression signatures, indicating that <jats:italic>CMYC<\/jats:italic> expression is ectopic and does not reflect the physiology of the normal cell counterpart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Additional cytogenetic, molecular and microarray investigations of NHL in children are vital to better understand these diseases, their etiology, and differences from adult NHL. A greater understanding of pediatric NHL will lead to disease\u2010specific and patient\u2010individualized therapies of these diseases. Pediatr Blood Cancer 2005;45:616\u2013622. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20552","type":"journal-article","created":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T18:46:36Z","timestamp":1125081996000},"page":"616-622","source":"Crossref","is-referenced-by-count":16,"title":["State of the Art and Future Needs in Cytogenetic\/Molecular Genetics\/Arrays in childhood lymphoma: Summary report of workshop at the First International Symposium on childhood and adolescent non\u2010Hodgkin lymphoma, April 9, 2003, New York City, NY"],"prefix":"10.1002","volume":"45","author":[{"given":"Nyla A.","family":"Heerema","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Bernheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan S.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Thomas","family":"Look","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pasqualucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Raetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren G.","family":"Sanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S.","family":"Cairo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,8,26]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70200-8"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199807000-00002"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.116"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0110"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20088"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1270"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00018-1"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-11-0093"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1495"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402892"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403061"},{"key":"e_1_2_4_13_2","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1182\/blood.V86.2.666.bloodjournal862666","article-title":"Does activation of the TAL1 gene occur in a majority of patients with T\u2010cell acute lymphoblastic leukemia? 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