{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T11:09:48Z","timestamp":1781953788841,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T00:00:00Z","timestamp":1124150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two brothers with hepatoblastoma were noted to have a family history of early onset colon cancer. Genetic testing of the younger brother revealed a deletion in exon 15 of the <jats:italic>adenomatous polyposis coli<\/jats:italic> (<jats:italic>APC<\/jats:italic>) gene (2710\u20102711delAG), consistent with a diagnosis of familial adenomatous polyposis (FAP). We review the clinical and molecular aspects of the relationship between hepatoblastoma and FAP, and the implications for diagnostic testing and cancer screening in affected patients. Pediatric Blood Cancer 2006;47:851\u2013854. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20556","type":"journal-article","created":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T19:47:01Z","timestamp":1124221621000},"page":"851-854","source":"Crossref","is-referenced-by-count":18,"title":["Familial adenomatous polyposis in two brothers with hepatoblastoma: Implications for diagnosis and screening"],"prefix":"10.1002","volume":"47","author":[{"given":"Robert P.","family":"Sanders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne L.","family":"Furman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,8,16]]},"reference":[{"key":"e_1_2_3_2_2","first-page":"848","volume-title":"Principles and practice of pediatric oncology","author":"Tomlinson GE","year":"2002"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11585"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/109.5.521"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.5.377"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.7.721"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.12.959"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.20.1626"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950170518"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320430621"},{"key":"e_1_2_3_11_2","first-page":"5007","article-title":"Biallelic inactivation of the APC gene in hepatoblastoma","volume":"55","author":"Kurahashi H","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.6.867"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00618-X"},{"key":"e_1_2_3_14_2","first-page":"3320","article-title":"Somatic mutations of the APC gene in sporadic hepatoblastomas","volume":"56","author":"Oda H","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10362"},{"key":"e_1_2_3_16_2","first-page":"269","article-title":"Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta\u2010catenin gene","volume":"59","author":"Koch A","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003830000576"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199908)25:4<399::AID-GCC14>3.0.CO;2-X"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203356"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1209"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00306-8"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.32.3.338"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012242"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00168-0"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050097"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900550"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20556","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T10:59:52Z","timestamp":1696676392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,16]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1002\/pbc.20556"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20556","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,16]]}}}