{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:29:20Z","timestamp":1792459760300,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,8,25]],"date-time":"2005-08-25T00:00:00Z","timestamp":1124928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present three cases of children with acute neurologic changes while undergoing induction chemotherapy for acute lymphoblastic leukemia (ALL). These cases fall into the spectrum of reversible posterior leukoencephalopathy syndrome (RPLS), including abrupt alterations in mental status, headache, seizures, visual changes, hypertension, and characteristic findings on magnetic resonance imaging. Although the underlying mechanism of RPLS is still under investigation, the appropriate treatment and management of the acute event is becoming clearer. Early treatment of hypertension, control of seizure activity, and withdrawal of inciting agents can lead to rapid reversal of symptoms and return to baseline functioning. Pediatr Blood Cancer 2007;49:198\u2013203. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20597","type":"journal-article","created":{"date-parts":[[2005,8,25]],"date-time":"2005-08-25T21:17:18Z","timestamp":1125004638000},"page":"198-203","source":"Crossref","is-referenced-by-count":33,"title":["Reversible posterior leukoencephalopathy syndrome in children undergoing induction therapy for acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"49","author":[{"given":"Jennifer K.","family":"Norman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie T.","family":"Parke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 Y.","family":"McNall\u2010Knapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,5]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602223340803"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307389901400502"},{"key":"e_1_2_4_4_2","first-page":"1199","article-title":"Posterior reversible encephalopathy syndrome: Utility of fluid\u2010attenuated inversion recovery MR imaging in the detection of cortical and subcortical lesions","volume":"21","author":"Casey SO","year":"2000","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(02)00508-8"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(98)00148-9"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(01)00217-X"},{"key":"e_1_2_4_8_2","first-page":"415","article-title":"Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome","volume":"19","author":"Ito Y","year":"1998","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200303000-00010"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050492"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(00)00242-3"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000065395"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10377"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1347-2"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(00)80357-6"},{"key":"e_1_2_4_16_2","first-page":"45","article-title":"Cyclosporine\u2010induced white and grey matter central nervous system lesions in a pediatric renal transplant patient","volume":"2","author":"Jeruss J","year":"1998","journal-title":"Pediatr Transplant"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1369"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000042095.49520.1E"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20597","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:39:24Z","timestamp":1699972764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,5]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1002\/pbc.20597"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20597","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,5]]}}}