{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:26Z","timestamp":1786978346072,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Invasive aspergillosis is an increasing problem in immuno\u2010incompetent patients after prolonged steroid therapy, cancer radio\u2010chemotherapy, and bone marrow or solid organ transplantation. Cerebral aspergillosis is a well\u2010described complication of the invasive aspergillosis but only in rare cases, the brain is the sole site of infection. Despite increasing availability of antifungal drugs, the prognosis of cerebral aspergillosis is poor. We report on an 11\u2010year\u2010old boy with medulloblastoma in the area of the fourth ventricle. Following tumor surgery and radio\u2010chemotherapy, several abscess\u2010like structures occurred in the operating field. After incomplete abscess, resection histology and culture confirmed a localized\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    infection. The initial treatment of the\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    infection with conventional amphotericin B failed, and treatment with the triazole voriconazole was started. Intravenous treatment with voriconazole resulted in a reduction of the\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    abscess. After switching to oral ambulatory therapy, the\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    abscess increased in size. To improve treatment, voriconazole dosage was adapted to reach drug concentrations in cerebrospinal fluid (CSF) above the minimal fungicidal concentration and plasma specimens. During the concentration\u2010controlled voriconazole therapy for a period of 18 months, a complete response was achieved. Pediatr Blood Cancer 2007;49:203\u2013207. \u00a9 2005 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/pbc.20628","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T19:20:27Z","timestamp":1133896827000},"page":"203-207","source":"Crossref","is-referenced-by-count":11,"title":["Successful treatment with voriconazole of Aspergillus brain abscess in a boy with medulloblastoma"],"prefix":"10.1002","volume":"49","author":[{"given":"M.","family":"Stiefel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Rei\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"Staege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rengelshausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Burhenne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wawer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Foell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,5]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/318483"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/513943"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.5.473"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365549609027182"},{"issue":"1","key":"e_1_2_4_6_2","first-page":"S42","article-title":"Update on the treatment of cerebral aspergillosis","volume":"83","author":"Schwartz S","year":"2004","journal-title":"Ann Hematol"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.3.608"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000028974"},{"key":"e_1_2_4_9_2","first-page":"87","article-title":"Sudden death secondary to fulminant intracranial aspegillosis in a healthy teenager after posterior fossa surgery: The role of corticosteroids and prophylactic recommendations","volume":"48","author":"Dickerman RD","year":"2004","journal-title":"J Neurosurg Sci"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007669411738"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.7.2348-2350.2003"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.3.696"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.972911.x"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.4.1186-1189.1999"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01967060"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200203000-00015"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199504000-00032"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2002.t01-2-02002.x"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/377131"},{"key":"e_1_2_4_20_2","first-page":"242","article-title":"Voriconazole\u2014Better chances for patients with invasive mycoses","volume":"7","author":"Ghannoum MA","year":"2002","journal-title":"Eur J Med Res"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.02.002"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200007000-00006"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20628","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T09:39:32Z","timestamp":1699954772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,5]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1002\/pbc.20628"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20628","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,5]]}}}