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After the sixth cycle of treatment with vincristine sulfate, 9 months after diagnosis, the child developed a rapidly progressive bilateral deterioration in visual acuity. Retinal appearances were consistent with optic neuropathy. Gene studies for neurocutaneous syndromes were negative. Brain imaging at this time showed no tumor progression, and in the absence of other etiologies, we implicate vincristine as a probable cause. Discontinuation of this particular agent has allowed bilateral improvement in visual acuity. Pediatr Blood Cancer 2007;48:238\u2013240. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20638","type":"journal-article","created":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T18:48:04Z","timestamp":1128365284000},"page":"238-240","source":"Crossref","is-referenced-by-count":20,"title":["Vincristine sulfate as a possible cause of optic neuropathy"],"prefix":"10.1002","volume":"48","author":[{"given":"James D.","family":"Weisfeld\u2010Adams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon N.","family":"Dutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dermot M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,3]]},"reference":[{"key":"e_1_2_2_2_2","first-page":"389","article-title":"Retinal and optic nerve atrophy induced by intravitreous vincristine in the primate","volume":"73","author":"Green WR","year":"1975","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_2_3_2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1542\/peds.70.2.288","article-title":"Optic atrophy induced by vincristine","volume":"70","author":"Shurin SB","year":"1982","journal-title":"Pediatrics"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(76)90725-X"},{"key":"e_1_2_2_5_2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3928\/0191-3913-19790501-15","article-title":"Unilateral optic neuropathy following vincristine chemotherapy","volume":"16","author":"Norton SW","year":"1975","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1988.4.117"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-199208000-00009"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520290115023"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.35.10.813"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.6.975"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.060"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/337944"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)90346-8"},{"key":"e_1_2_2_14_2","first-page":"235","article-title":"Radiation\u2010induced optic neuropathy: Characteristic appearances on gadolinium\u2010enhanced MR","volume":"13","author":"Hudgins PA","year":"1992","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(85)33898-8"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10397"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20638","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T16:46:06Z","timestamp":1699980366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,3]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1002\/pbc.20638"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20638","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,3]]}}}