{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:45:26Z","timestamp":1778939126163,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,10,31]],"date-time":"2005-10-31T00:00:00Z","timestamp":1130716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2006,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chromosome abnormalities often occur prenatally in childhood leukemia, characterizing an early event in leukemogenesis. The majority of the abnormalities occurring in infants involve the <jats:italic>MLL<\/jats:italic> gene on chromosome band 11q23. We describe the molecular cytogenetic findings of 207 infant acute leukemia (IAL) cases included in the Brazilian Collaborative Study Group of Infant acute leukemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The diagnosis of Acute Lymphoblastic leukemia (ALL) or acute myeloblastic leukemia (AML) was made according to morphology and immunophenotyping classification, followed by conventional karyotyping. Samples were then screened using RT\u2010PCR for the presence of specific chromosome translocations. FISH assay for <jats:italic>MLL<\/jats:italic> rearrangements was performed only in cases with negative or inconclusive cytogenetic or PCR results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The characteristics of children with IAL were as follows: 115 boys and 92 girls, age range 0\u201323 months, mean age 12 months, 145 ALL, and 62 AML. A statistically significant association was observed between pro\u2010B ALL cases and <jats:italic>MLL<\/jats:italic><jats:sup>+ve<\/jats:sup> (<jats:italic>P<\/jats:italic>\u2009=\u20090.0001) cases and the age group 0\u20133 months with <jats:italic>MLL<\/jats:italic><jats:sup>+ve<\/jats:sup> (<jats:italic>P<\/jats:italic>\u2009=\u20090.008) cases. Two rare cases of pro\u2010T ALL with <jats:italic>MLL<\/jats:italic><jats:sup>+ve<\/jats:sup> were found. Other than <jats:italic>MLL<\/jats:italic> rearrangements, various other molecular aberrations were detected including <jats:italic>TEL\/AML1<\/jats:italic><jats:sup>+ve<\/jats:sup> (n\u2009=\u20099), <jats:italic>E2A\/PBX1<\/jats:italic><jats:sup>+ve<\/jats:sup> (n\u2009=\u20094), <jats:italic>PML\/RARA<\/jats:italic><jats:sup>+ve<\/jats:sup> (n\u2009=\u20094), and <jats:italic>AML1\/ETO<\/jats:italic><jats:sup>+ve<\/jats:sup> (n\u2009=\u20092). Cytogenetic analysis revealed hyperdiploidy (n\u2009=\u20096), del(7) in two cases and del(11)(q23) in seven cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results show that not only <jats:italic>MLL<\/jats:italic> rearrangements, but also other molecular abnormalities occur before birth and may contribute to leukemogenesis. Pediatr Blood Cancer 2006; 47:549\u2013554. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.20654","type":"journal-article","created":{"date-parts":[[2005,10,31]],"date-time":"2005-10-31T22:16:34Z","timestamp":1130796994000},"page":"549-554","source":"Crossref","is-referenced-by-count":28,"title":["Molecular cytogenetic findings of acute leukemia included in the Brazilian Collaborative Study Group of Infant acute leukemia"],"prefix":"10.1002","volume":"47","author":[{"given":"Mariana","family":"Emerenciano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Patricia","family":"Agudelo Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia Maria","family":"Coser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilena Dantas","family":"de Brito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L.","family":"Macedo Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.","family":"Pombo\u2010de\u2010Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/363358a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401344"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.070061297"},{"key":"e_1_2_6_5_2","unstructured":"Abstracts of the American Society of Hematology 45th Annual Meeting. 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