{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:14Z","timestamp":1786978274540,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2006,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai\u2013Dorfman disease (RDD) is a rare but well\u2010defined histiocytic proliferative disorder of unknown etiology that usually presents with cervical lymphadenopathy, fever, leukocytosis, and hypergammaglobulinemia in an otherwise healthy child. Although many patients undergo spontaneous remission, a subset of patients with systemic disease has a more serious course. For those patients with a poor outcome, steroids and chemotherapeutic agents such as etoposide or 6\u2010mercaptopurine plus low dose methotrexate have been used. We present a child with a massive cervical lymphadenopathy treated with 2\u2010chlorodeoxyadenosine (2\u2010CdA, cladribine) after other approaches failed. Pediatr Blood Cancer 2006; 47:612\u2013615. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20668","type":"journal-article","created":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T14:46:26Z","timestamp":1132584386000},"page":"612-615","source":"Crossref","is-referenced-by-count":38,"title":["Sinus histiocytosis with massive lymphadenopathy (Rosai\u2013Dorfman disease) treated with 2\u2010chlorodeoxyadenosine"],"prefix":"10.1002","volume":"47","author":[{"given":"M.","family":"Tasso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Esquembre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Moscard\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Niveiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pay\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"63","article-title":"Sinus histiocytosis with massive lymphadenopathy: A newly recognized benign clinicopathological entity","volume":"87","author":"Rosai J","year":"1969","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/hn.1999.v120.a84677"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199609)27:3<187::AID-MPO10>3.0.CO;2-D"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1991.tb00001.x"},{"key":"e_1_2_4_6_2","first-page":"1911","volume-title":"Rosai and Ackerman surgical pathology","author":"Rosai J","year":"2004"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200101)24:1<42::AID-DC1007>3.0.CO;2-N"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.1998.00101.x"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000332719"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199605)179:1<60::AID-PATH533>3.0.CO;2-F"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199407213310303"},{"key":"e_1_2_4_12_2","first-page":"117A","article-title":"Molecular assessment of clonality in sinus histiocytosis with massive limphadenopathy (SHML). 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