{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T19:10:05Z","timestamp":1700075405769},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T00:00:00Z","timestamp":1137542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Essential thrombocythemia (ET) is a clonal myeloproliferative disorder characterized by sustained thrombocytosis, isolated hyperplasia of megakaryocytic lineage, and association with thrombotic or bleeding episodes. It is extremely rare in childhood and frequently presents without evident clinical signs. We describe a 3\u2010year\u2010old girl with severe headache and dizziness suffering from ET, who was treated with Interferon\u2010alpha\u20102a (IFN) based on the potent effect of this agent to inhibit myeloid colonies induced by phytohemagglutinin A stimulated leukocyte conditioned medium (PHA\u2010LCM). Bone\u2010marrow\u2010derived mononuclear cells of this patient did not exhibit spontaneous colony formation but responded to recombinant human (rh) erythropoietin (EPO), rh granulocyte\u2010colony stimulating factor (G\u2010CSF), granulocyte\u2010macrophage (GM)\u2010CSF, and stem\u2010cell factor in addition to PHA\u2010LCM. After 65 months of in vivo IFN treatment, the patient experienced a sustained partial remission with platelet counts varying between 400 and 600\u2009\u00d7\u200910<jats:sup>3<\/jats:sup>\/\u00b5l. Pediatr Blood Cancer 2007;49:744\u2013747. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20744","type":"journal-article","created":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T21:50:06Z","timestamp":1137621006000},"page":"744-747","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010lasting partial remission by Interferon\u2010alpha treatment in a child with essential thrombocythemia"],"prefix":"10.1002","volume":"49","author":[{"given":"Istv\u00e1n","family":"Szegedi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Benk\u0151","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Mer\u0151","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gota","family":"Prinzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Kappelmayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csongor","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01545.x"},{"key":"e_1_2_5_3_2","first-page":"309","article-title":"Thrombocytosis in children at one medical center of southern Taiwan","volume":"40","author":"Chen HL","year":"1999","journal-title":"Acta Pediatr Taiwan"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02239-7.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21086"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002100000390"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(00)00389-7"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20185"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01817.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402574"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb04251.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537100400020179"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0369-8114(03)00038-5"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996102"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996123"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.6.2093.h8002093_2093_2099"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.2303047.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199609074371"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200407000-00017"},{"key":"e_1_2_5_20_2","first-page":"217","article-title":"Essential thrombocythemia: An interim report from Polycythemia Vera Study Group","volume":"23","author":"Murphy S","year":"1986","journal-title":"Semin Hematol"},{"key":"e_1_2_5_21_2","first-page":"1417","article-title":"Inhibition of activated blood platelets by interferon alpha 2b in chronic hepatitis C","volume":"51","author":"Panasiuk A","year":"2004","journal-title":"Hepatogastroenterology"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20744","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:40:21Z","timestamp":1700073621000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,18]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,10,15]]}},"alternative-id":["10.1002\/pbc.20744"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20744","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,18]]}}}