{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T17:37:47Z","timestamp":1765993067685},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T00:00:00Z","timestamp":1141257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the value of follow\u2010up investigations of T\u2010cell acute lymphoblastic leukemia (T\u2010ALL) and T\u2010cell non\u2010Hodgkin's lymphoma (T\u2010NHL), including cerebrospinal fluid (CSF) examination, bone marrow (BM) aspiration, peripheral blood (PB) count, serum lactate dehydrogenase (LDH) and chest X\u2010rays in patients with an initial mediastinal enlargement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We reviewed clinical records of all T\u2010ALL patients from 1987 to 2002 and all T\u2010NHL patients from 1977 to 2002, seen at a single institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 48 T\u2010ALL patients, 15 suffered from a relapse, 6 (40%) were asymptomatic at the time of relapse. T\u2010ALL (13\/30) with mediastinal enlargement at first diagnosis relapsed versus 2\/16 of those without mediastinal enlargement. However, at relapse, only one patient had a mediastinal mass, which in addition was symptomatic. Of 39 T\u2010NHL patients, 6 patients relapsed. Forty percent of relapsed T\u2010ALL and 17% of relapsed T\u2010NHL were asymptomatic. The seven asymptomatic relapses were detected by CSF (n\u2009=\u20094), BM (n\u2009=\u20092) or blood count (n\u2009=\u20091) examinations. All T\u2010ALL and T\u2010NHL patients with a mediastinal relapse were symptomatic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that routine CSF examinations during treatment can detect relapses of T\u2010ALL and T\u2010NHL before onset of symptoms, which might be of clinical value. Relapses are rarely detected by BM or blood examinations and whether this translates in a clinical benefit is unlikely. Routine chest X\u2010rays are not useful. 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