{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T13:04:24Z","timestamp":1754399064018},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T00:00:00Z","timestamp":1149811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe a female with a history of autosomal recessive hyper\u2010IgM (HIGM) syndrome along with a history of autoimmune hemolytic anemia and intermittent lymphadenopathy. She subsequently developed neutropenia, lymphocyostosis and mild thrombocytopenia. Flow cytometry of the peripheral blood revealed the presence of a marked predominance of cytotoxic T lymphocytes, shown to be clonal, with concomitant natural killer (NK) antigen expression. She responded to weekly methotrexate therapy. Pediatr Blood Cancer 2008;50:142\u2013145. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.20902","type":"journal-article","created":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T18:03:41Z","timestamp":1149876221000},"page":"142-145","source":"Crossref","is-referenced-by-count":11,"title":["Large granular lymphocyte leukemia (LGL) in a child with hyper IgM syndrome and autoimmune hemolytic anemia"],"prefix":"10.1002","volume":"50","author":[{"given":"Brenda J.","family":"Kitchen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence A.","family":"Boxer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(03)00133-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.10378"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/107327489800500103"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.1.256"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-2-169"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90422-3"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.6.567"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.12.4771"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.10.3219"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1449.h81602001449_1449_1453"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01661"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370909"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400406"},{"key":"e_1_2_5_16_2","first-page":"307","article-title":"Humoral and cellular immune mechanisms of neutropenia in patients with Felty's syndrome","volume":"39","author":"Starkebaum G","year":"1980","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0396-317"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.2.429"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.7.3666"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.7.2164.2164"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1620.bloodjournal8451620"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.20902","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.20902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:16:52Z","timestamp":1696907812000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.20902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,19]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/pbc.20902"],"URL":"https:\/\/doi.org\/10.1002\/pbc.20902","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,19]]}}}