{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:52:07Z","timestamp":1791003127898,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T00:00:00Z","timestamp":1155859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007737","name":"St. Jude Children's Research Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007737","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006458","name":"The Children's Hospital of Philadelphia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006458","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Comparison of functional mobility and quality of life is performed in patients with lower\u2010extremity bone sarcoma following either amputation, limb\u2010sparing surgery, or rotationplasty with four different types of outcome measures: (1) an objective functional mobility measure that requires patients to physically perform specific tasks, functional mobility assessment (FMA); (2) a clinician administered tool, Musculoskeletal Tumor Society Scale (MSTS); (3) a patient questionnaire, Toronto Extremity Salvage Scale (TESS); and (4) a health\u2010related quality of life (HRQL) measure, Short Form\u201036 version 2 (SF\u201036v.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>This is a prospective multi\u2010site study including 91 patients with lower\u2010extremity bone sarcoma following amputation, limb\u2010sparing surgery, or rotationplasty. One of three physical therapists administered the quality of life measure (SF\u201036v.2) as well as a battery of functional measures (FMA, MSTS, and TESS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Differences between patients who had amputation, limb\u2010sparing surgery, or rotationplasty were consistently demonstrated by the FMA. Patients with limb sparing femur surgery performed better than those patients with an above the knee amputation but similarly to a small number of rotationplasty patients. Several of the more conventional self\u2010report measures were shown to not have the discriminative capabilities of the FMA in these cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In adolescents with lower\u2010extremity bone sarcoma, it may be advantageous to consider the use of a combination of outcome measures, including the FMA, for objective functional mobility assessment along with the TESS for a subjective measure of disability and the SF\u201036v.2 for a quality\u2010of\u2010life measure. Pediatr Blood Cancer 2007;49:964\u2013969. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21018","type":"journal-article","created":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T21:18:26Z","timestamp":1155935906000},"page":"964-969","source":"Crossref","is-referenced-by-count":110,"title":["A comparative analysis of functional outcomes in adolescents and young adults with lower\u2010extremity bone sarcoma"],"prefix":"10.1002","volume":"49","author":[{"given":"Jill P.","family":"Ginsberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shesh N.","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire A.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna 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