{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:09:29Z","timestamp":1777486169414,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T00:00:00Z","timestamp":1157587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term writing difficulties in children after treatment with vincristine for acute lymphoblastic leukemia, Wilms tumor, B non\u2010Hodgkin lymphoma, and malignant mesenchymal tumors, were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Handwriting of 33 survivors and 33 controls matched for age, sex, and grade, was assessed with the BHK\u2010scale. The examiner was blinded for whether a child was a case or a control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference in writing speed was found. Mean difference in number of letters produced during 5 min was 6.4 (\u00b167.1, range \u2212103 to +169). No significant difference was found in quality of writing scores; mean difference in points was 1.5 (\u00b17.7, range \u221219 to +22). Cumulative vincristine dose, age at diagnosis or time since completion of treatment did not affect writing speed or quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chemotherapy, including vincristine, does not lead to long\u2010term problems in speed or quality of writing in children treated for cancer. Pediatr Blood Cancer 2007;49:841\u2013845. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21023","type":"journal-article","created":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T18:51:52Z","timestamp":1157655112000},"page":"841-845","source":"Crossref","is-referenced-by-count":9,"title":["No adverse effect of vincristine on handwriting in children after completion of therapy"],"prefix":"10.1002","volume":"49","author":[{"given":"A.","family":"Hartman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"van den Bos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"van Dartel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th.","family":"Stijnen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Pieters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30259-7"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910501)67:9<2241::AID-CNCR2820670905>3.0.CO;2-A"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01050259"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02072486"},{"key":"e_1_2_5_6_2","volume-title":"Neurologic complications of cancer","author":"Posner JB","year":"1995"},{"key":"e_1_2_5_7_2","volume-title":"Peripheral neuropathy in childhood","author":"Ouvrier RA","year":"1999"},{"key":"e_1_2_5_8_2","first-page":"353","article-title":"Specific learning problems among children treated for acute lymphoblastic leukemia","volume":"4","author":"Cousens P","year":"1997","journal-title":"Int J Ped Hematol\/Oncol"},{"key":"e_1_2_5_9_2","first-page":"215","volume-title":"Handwriting and drawing research: Basic and applied issues","author":"Reinders\u2010Messelink H","year":"1996"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21706"},{"key":"e_1_2_5_11_2","volume-title":"Movement assessment battery for children","author":"Henderson S","year":"1992"},{"key":"e_1_2_5_12_2","volume-title":"Movement assessment battery for children; 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