{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:57:44Z","timestamp":1790002664053,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T00:00:00Z","timestamp":1158796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brain tumors (BT) are second only to acute lymphoblastic leukemia as the most prevalent form of pediatric cancer, with BT 5\u2010year survival rates approaching 70%. With increased survival, quality of life has emerged as an essential health outcome. This investigation examines the internal consistency reliability and construct validity of the Pediatric Quality of Life Inventory\u2122 (PedsQL\u2122) Brain Tumor Module.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PedsQL\u2122 4.0 Generic Core Scales, PedsQL\u2122 Multidimensional Fatigue Scale, and PedsQL\u2122 Brain Tumor Module were administered to 99 families. The average age of the 56 boys and 43 girls was 9.76 years (range\u2009=\u20092\u201318 years). The sample included children with tumors located in the posterior fossa\/brainstem (N\u2009=\u200962, 62.6%), supratentorial (N\u2009=\u200915, 15.2%), and midline (N\u2009=\u200922, 22.2%). Children were on treatment (N\u2009=\u200946, 46.5%), off treatment &lt;12 months (N\u2009=\u200919, 19.2%), or off treatment &gt;12 months\/long\u2010term survivor (N\u2009=\u200934, 34.3%). Treatment included radiation (N\u2009=\u200961, 61.6%), surgery (N\u2009=\u200983, 83.8%), chemotherapy (N\u2009=\u200987, 87.9%), and bone marrow transplant (N\u2009=\u20095, 5.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Internal consistency reliability was demonstrated for the 24\u2010item PedsQL\u2122 Brain Tumor Module (average \u03b1\u2009=\u20090.78\u20130.92, parent proxy\u2010report, n\u2009=\u200999; average \u03b1\u2009=\u20090.76\u20130.87, child self\u2010report, n\u2009=\u200951). Construct validity for the PedsQL\u2122 Brain Tumor Module was supported through an analysis of the intercorrelations with the Generic Core Scales and Fatigue Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings provide support for the measurement properties of the PedsQL\u2122 Brain Tumor Module. Pediatr Blood Cancer 2007;49:287\u2013293. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21026","type":"journal-article","created":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T20:55:51Z","timestamp":1158872151000},"page":"287-293","source":"Crossref","is-referenced-by-count":142,"title":["The PedsQL\u2122 brain tumor module: Initial reliability and validity"],"prefix":"10.1002","volume":"49","author":[{"given":"Stephanie N.","family":"Palmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Meeske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest R.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasha M.","family":"Burwinkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Varni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.53.1.5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.10.190"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20609"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1367\/A03-112R.1"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2004.71273.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10428"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2214.2003.00318.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-3-29"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000087066"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199902000-00003"},{"key":"e_1_2_7_12_2","first-page":"2494","article-title":"The PedsQL\u2122 Multidimensional Fatigue Scale in pediatric rheumatology: Reliability and validity","volume":"31","author":"Varni JW","year":"2004","journal-title":"J Rheum"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026490117121"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/0470846283"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2005.tb01209.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200108000-00006"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1367\/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2"},{"key":"e_1_2_7_18_2","volume-title":"Designing and conducting health surveys: A comprehensive guide","author":"Aday LA","year":"1996"},{"key":"e_1_2_7_19_2","volume-title":"Answering questions: Methodology for determining cognitive and communicative processes in survey research","author":"Schwarz N","year":"1996"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1201\/9781420035438"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0148-9062(75)90418-0"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02310555"},{"key":"e_1_2_7_23_2","volume-title":"Psychometric theory","author":"Nunnally JC","year":"1994"},{"key":"e_1_2_7_24_2","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_7_25_2","volume-title":"Measurement, design, and analysis: An integrated approach","author":"Pedhazur EJ","year":"1991"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1966.19.1.3"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016647407161"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02289400"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:QURE.0000021686.47079.0d"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.5.6.705"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950200302"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688639408402615"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-005-1388-z"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:QURE.0000018483.01526.ab"}],"container-title":["Pediatric Blood &amp; 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