{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:47:05Z","timestamp":1791499625598,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,9,13]],"date-time":"2006-09-13T00:00:00Z","timestamp":1158105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Advances in treatment have improved the prognosis in \u03b2\u2010thalassemia major. We present the survival and complications pattern of those patients in northern Taiwan born after 1970.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>One\u2010hundred and sixty patients with \u03b2\u2010thalassemia major born after 1970 were collected. The Kaplan\u2013Meier method and log\u2010rank test were used to estimate and compare survival. Cox regression models were used to examine the associations of bone marrow transplantation (BMT), time of BMT procedure, and time of complications with survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Better survival was observed for patients born after 1980 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0121). Heart disease, BMT\u2010related deaths, and infections were the main causes of death. Among the living patients over age 15, hypogonadotropic hypogonadism, HCV infection, diabetes, heart failure, and arrhythmia were the common complications. No patients under age 15 had complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Survival for patients with \u03b2\u2010thalassemia major has improved significantly in Taiwan. More time is required to demonstrate whether these modalities added to the treatment of these patients will impact favorably on their outcome. Our success with BMT is improving and we are now in a position to offer this curative alternative. Pediatr Blood Cancer 2007;48:550\u2013554. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21028","type":"journal-article","created":{"date-parts":[[2006,9,13]],"date-time":"2006-09-13T19:53:33Z","timestamp":1158177213000},"page":"550-554","source":"Crossref","is-referenced-by-count":33,"title":["Survival, mortality, and complications in patients with \u03b2\u2010Thalassemia major in northern Taiwan"],"prefix":"10.1002","volume":"48","author":[{"given":"Jimmy P. S.","family":"Chern","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syi","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Hsin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Hui","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Yao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiann\u2010Tarng","family":"Jou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Tsamn","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Ling","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Sin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"678","article-title":"Incidence study of heterozygous \u03b2\u2010thalassemia in northern Taiwan","volume":"88","author":"Ko TM","year":"1989","journal-title":"Taiwan Yi Xue Hui Za Zhi"},{"key":"e_1_2_5_3_2","first-page":"119","article-title":"Clinical observation of \u03b2\u2010thalassemia in infants and children","volume":"16","author":"Tsai MD","year":"1975","journal-title":"Acta Paediatr Sin"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198506203122503"},{"key":"e_1_2_5_5_2","first-page":"126","article-title":"Results of therapy for beta\u2010thalassemia major","volume":"91","author":"Lin KH","year":"1992","journal-title":"J Formos Med Assoc"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409013310902"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409013310903"},{"key":"e_1_2_5_8_2","first-page":"1187","article-title":"Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine","volume":"89","author":"Borgna\u2010Pignatti C","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1345.006"},{"key":"e_1_2_5_10_2","first-page":"115","article-title":"Marrow transplantation for thalassemia","volume":"1","author":"Lin KH","year":"1986","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.284.6322.1081"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90264-X"},{"key":"e_1_2_5_13_2","unstructured":"http:\/\/www.moi.gov.tw\/stat\/english\/index.asp."},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02357-6"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)01105-1"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.02.003"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/367656"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/382683"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/378062"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000076630"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200311000-00011"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.5.850"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T20:08:55Z","timestamp":1697659735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,2]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1002\/pbc.21028"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21028","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,2]]}}}