{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:32:01Z","timestamp":1781109121022,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T00:00:00Z","timestamp":1156464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pancreatitis is a well\u2010known, but little\u2010understood complication of asparaginase. There is no predictor of who will develop asparaginase\u2010associated pancreatitis (AAP). To better define this population, we present a retrospective analysis regarding AAP and provide a review of the relevant literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically reviewed medical records of 254 asparaginase recipients during a 5\u2010year period. Pancreatitis was defined and graded according to CTCAE v3.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pancreatitis was diagnosed in 48 (19%) patients. Thirty\u2010three (13%) patients were identified as having AAP. Twelve cases occurred after <jats:italic>Escherichia coli<\/jats:italic> asparaginase and 20 followed PEG\u2010asparaginase. Pancreatitis was independent of the individual or cumulative asparaginase dose. The interval to pancreatitis diagnosis was longer for PEG\u2010asparaginase than <jats:italic>E. coli<\/jats:italic> asparaginase (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). AAP was seen more frequently in patients receiving prednisone (<jats:italic>P<\/jats:italic>\u2009=\u20090.02) and daunomycin (<jats:italic>P<\/jats:italic>\u2009=\u20090.006) while less frequent with dexamethasone (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). Other chemotherapy agents appeared to have no association with AAP. As observed by others, those with pancreatitis were older (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), but the significance of this remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study emphasizes our inability to predict who will develop pancreatic toxicity from asparaginase and suggests that those at risk might have an unidentified genetic predisposition. Pediatr Blood Cancer 2007;49:634\u2013639. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21037","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T21:37:06Z","timestamp":1156541826000},"page":"634-639","source":"Crossref","is-referenced-by-count":85,"title":["Predicting asparaginase\u2010associated pancreatitis"],"prefix":"10.1002","volume":"49","author":[{"given":"Holly M.","family":"Knoderer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Robarge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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