{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:55:38Z","timestamp":1783407338263,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T00:00:00Z","timestamp":1158883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of comprehensive care on utilization of healthcare services by children with sickle cell disease (SCD) has not been fully evaluated. We compared the medical care utilization and mortality in children less than 20 years of age with SCD in four regions in the state of Tennessee with and without a comprehensive sickle cell center (CSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rates of hospitalizations, outpatient and emergency department (ED) visits, and deaths were measured in a cohort of children aged &lt;20 years with SCD, enrolled in TennCare, from January 1995 to December 2002. TennCare data linked to Tennessee vital records were used to define the population and identify the outcomes. The patients were classified into one of four regions based on their residential address on the day of their hospitalization or outpatient visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort consisted of 1,214 children with 6,393 person\u2010years of follow\u2010up. Fifty\u2010six percent of patients resided in the region with the CSCC. This region had the highest overall rates of hospitalization for all children (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), while ED and outpatient visits were higher in other areas. The death rates ranged from 1.8 to 4.3 per 1,000 person\u2010years in the four regions and did not represent statistically significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No clear pattern of improved utilization of medical care services were identified in relation to proximity of residence to a CSCC. This cohort was not large enough to detect small differences in death rates. In addition, other outcomes that incorporate quality of life measures may be more sensitive to differences in medical care. Pediatr Blood Cancer 2008;50:66\u201371. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21066","type":"journal-article","created":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T18:59:12Z","timestamp":1158951552000},"page":"66-71","source":"Crossref","is-referenced-by-count":29,"title":["Impact of proximity to comprehensive sickle cell center on utilization of healthcare services among children with sickle cell disease"],"prefix":"10.1002","volume":"50","author":[{"given":"Sadhna M.","family":"Shankar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick G.","family":"Arbogast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Mitchel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfred C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie R.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.81.6.749"},{"key":"e_1_2_5_3_2","first-page":"220","article-title":"Comprehensive care in sickle cell disease: Its impact on morbidity and mortality","volume":"28","author":"Vichinsky EP","year":"1991","journal-title":"Semin Hematol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830390305"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7020.1600"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70426-0"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904013401307"},{"key":"e_1_2_5_8_2","volume-title":"Sickle Cell Disease","author":"Serjeant G","year":"2001"},{"key":"e_1_2_5_9_2","unstructured":"National Newborn Screening Report\u20101992. 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