{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:44:51Z","timestamp":1759340691545},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T00:00:00Z","timestamp":1161734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myelodysplastic syndrome (MDS) in children is often associated with chromosomal anomalies and trisomy 8 is a characteristic karyotypic feature in up to 20% of the cases. Beh\u00e7et disease is a rare multisystem inflammatory disorder characterized by recurrent mouth and genital ulcers. MDS with trisomy 8 has been observed in adult patients with Beh\u00e7et syndrome with some cases developing prior to the clinical manifestations of the latter. We present a female with a similar association and explain the importance of identifying the coexisting conditions. The immunological abnormalities, which may be observed in MDS and their possible mechanisms, are also discussed. Pediatr Blood Cancer 2008;50:649\u2013651. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21075","type":"journal-article","created":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T17:48:40Z","timestamp":1161798520000},"page":"649-651","source":"Crossref","is-referenced-by-count":11,"title":["Myelodysplastic syndrome with trisomy 8 associated with Beh\u00e7et syndrome: An immunologic link to a karyotypic abnormality"],"prefix":"10.1002","volume":"50","author":[{"given":"Jecko V.","family":"Thachil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahuman","family":"Salim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Field","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Moots","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Bolton\u2010Maggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,9]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"1078","article-title":"Criteria for diagnosis of Behcet's disease","volume":"335","author":"International Study Group for Behcet's Disease","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100670170036"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970115)79:2<262::AID-CNCR9>3.0.CO;2-M"},{"key":"e_1_2_4_5_2","first-page":"721","article-title":"Rheumatic manifestations in myelodysplastic syndromes","volume":"18","author":"Castro M","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199709055585"},{"key":"e_1_2_4_7_2","first-page":"95","article-title":"Joint manifestations in myelodysplastic syndromes. 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