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Further evaluation revealed secondary hyperparathyroidism, highly elevated alkaline phosphatase levels, and generalized sclerotic and lytic lesions. Biopsy confirmed osteosarcomatosis. Despite aggressive chemotherapy, he died from progressive disease 2 months after diagnosis. The course of disease in this patient suggests that hypocalcemia reflects a poor prognosis. Pediatr Blood Cancer 2008;50:687\u2013689. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21102","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T09:22:40Z","timestamp":1170494560000},"page":"687-689","source":"Crossref","is-referenced-by-count":8,"title":["Hypocalcemia as a presentation for multifocal osteosarcoma"],"prefix":"10.1002","volume":"50","author":[{"given":"Akbar","family":"Soltani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Hasani\u2010Ranjbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Moayyeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907293410507"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197911)44:5<1897::AID-CNCR2820440552>3.0.CO;2-2"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2001.13.3.324"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199901000-00013"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199710000-00014"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00563212"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950210206"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050289"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196911)24:5<923::AID-CNCR2820240509>3.0.CO;2-E"},{"key":"e_1_2_5_11_2","first-page":"645","volume-title":"Vitamin D","author":"Parfitt AM","year":"1997"},{"key":"e_1_2_5_12_2","first-page":"1717","volume-title":"The metabolic and molecular basis of acquired disease","author":"Stanbury SW","year":"1990"},{"key":"e_1_2_5_13_2","first-page":"663","volume-title":"Vitamin D","author":"Pettifor JM","year":"1997"},{"key":"e_1_2_5_14_2","first-page":"413","article-title":"The importance of limited exposure to ultraviolet radiation and dietary factors in the aetiology of Asian rickets: A risk\u2010factor model","volume":"63","author":"Henderson JB","year":"1987","journal-title":"Q J Med"},{"key":"e_1_2_5_15_2","first-page":"331","volume-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","author":"Drezner MK","year":"1999"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100240050008"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T19:59:15Z","timestamp":1696881555000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,9]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/pbc.21102"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21102","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,9]]}}}