{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:09:32Z","timestamp":1761487772112},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T00:00:00Z","timestamp":1170374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Disseminated adenoviral infection with hepatitis is rare in children undergoing standard chemotherapy. We report on a 3<jats:bold>\u00bd<\/jats:bold>\u2010year\u2010old male with fatal adenovirus hepatitis receiving maintenance chemotherapy for acute lymphoblastic leukemia (ALL). Adenoviral hepatitis was proven by histology, viral culture, and PCR in a liver biopsy. Quantitative real\u2010time PCR in the peripheral blood showed adenoviral DNA copy number &gt;10<jats:sup>9<\/jats:sup>\/ml. Despite aggressive supportive care and antiviral treatment with cidofovir, the patient died rapidly due to fulminant liver failure. Diagnostic and treatment options for adenovirus infection remain unsatisfactory for these patients. We propose suggestions for diagnosis and therapy. Pediatr Blood Cancer 2008;50:647\u2013649. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21120","type":"journal-article","created":{"date-parts":[[2007,2,4]],"date-time":"2007-02-04T02:38:14Z","timestamp":1170556694000},"page":"647-649","source":"Crossref","is-referenced-by-count":38,"title":["Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"50","author":[{"given":"Isabelle","family":"Steiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Aebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Ridolfi L\u00fcthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bendicht","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Leibundgut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2152"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703798"},{"key":"e_1_2_5_4_2","first-page":"1843","volume-title":"Textbook of Pediatric Infectious Disease. 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