{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:26:29Z","timestamp":1787772389689,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T00:00:00Z","timestamp":1169424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Children with sickle cell anemia (SCA) have low bone mass though bone turnover has not been well described. In this study, growth and pubertal development were assessed twice, 1 year apart, in 80 young subjects with type\u2010SS SCA, while whole body bone mineral content (BMC) and density where measured in a subset (n\u2009=\u200946). Markers of bone turnover were measured at the second visit. Bone formation (alkaline phosphatase) was elevated, whereas bone resorption (deoxypryidinoline) was decreased compared to published data in healthy children. Markers of bone turnover correlated with growth velocity and pubertal development but not with changes in bone mass. Pediatr Blood Cancer 2008;50:620\u2013623. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21147","type":"journal-article","created":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T20:47:56Z","timestamp":1169498876000},"page":"620-623","source":"Crossref","is-referenced-by-count":23,"title":["Markers of bone turnover are associated with growth and development in young subjects with sickle cell anemia"],"prefix":"10.1002","volume":"50","author":[{"given":"Ellen B.","family":"Fung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Kawchak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette S.","family":"Zemel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha J.","family":"Rovner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwaku","family":"Ohene\u2010Frempong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia A.","family":"Stallings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20681"},{"key":"e_1_2_6_3_2","first-page":"43","article-title":"Bone mineral density of lumbar spine and proximal femur in children with sickle cell disease","volume":"27","author":"Brinker MR","year":"1998","journal-title":"Am J Orthopedics"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2582"},{"key":"e_1_2_6_5_2","first-page":"240","volume-title":"Sickle Cell Disease","author":"Serjeant G","year":"2001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00180461"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)90053-2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/44.4.194"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.06.055"},{"key":"e_1_2_6_10_2","first-page":"44","article-title":"Nutrition assessment in children with sickle cell disease","volume":"8","author":"Williams R","year":"1997","journal-title":"J Assoc Acad Minority Physicians"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070020"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088471"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.10.1664"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/clinchem\/48.2.315","article-title":"Collagen markers deoxypyridinoline and hydroxylysine glycosides: Pediatric reference data and use for growth prediction in growth hormone deficient children","volume":"48","author":"Rauch F","year":"2002","journal-title":"Clin Chem"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/07435800500371607"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1742-1241.1998.tb08939.x","article-title":"Bone and collagen markers in pediatric practice","volume":"52","author":"Crofton PM","year":"1998","journal-title":"Int J Clin Pract"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-1107-x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.3.E518"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1163\/15685590151092706"},{"key":"e_1_2_6_20_2","first-page":"1318","volume-title":"Williams Textbook of Endocrinology","author":"Bringhurst FR","year":"2003"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/75.2.300"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21147","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T20:00:20Z","timestamp":1696881620000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,9]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/pbc.21147"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21147","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,9]]}}}