{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:08:54Z","timestamp":1764781734291},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fanconi anemia (FA) is a genetic disorder associated with multiple congenital anomalies, bone marrow failure, and pituitary hypofunction including hypogonadism, thyroid dysfunction, and growth hormone (GH) deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Among 44 patients with FA referred to Cincinnati Children's Hospital Medical Center (CCHMC) between 1975 and 2005, 33 had neuroimaging studies, including 11 cranial magnetic resonance imaging (MRIs). Two separate measurements per patient from these MRIs were used to evaluate pituitary height compared to on\u2010site control data of similar measurements of cranial MRIs on 22 age and gender\u2010matched children without any pathology involving the hypothalamic\u2010pituitary system. Growth pattern and endocrine studies were reviewed to assess potential correlation with pituitary size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When compared to the age\u2010gender matched on\u2010site control sample, the mean pituitary height of FA patients was significantly smaller (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001; mean\u2009\u00b1\u2009SE from mixed effects model with age and gender as covariates: 3.96\u2009\u00b1\u20090.32 vs. 5.76\u2009\u00b1\u20090.24). Upon further adjusting for the effect of the small head size by including bi\u2010parietal diameter (BPD) as a covariate, the difference remained statistically significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.0013). Findings on the growth pattern and endocrinological measurements are as follows: 50% of patients with small pituitary gland were short. GH and adrenal function tests were normal in all tested patients. Thyroid, pubertal status, and glucose regulation were abnormal in 30, 50, and 75% of patients tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children with FA tend to have unsuspected small pituitary glands beyond what is expected from the effects of their stunted growth. Further studies are required to reveal the clinical implications of this finding. Pediatr Blood Cancer 2007;49:166\u2013170. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21148","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T09:06:36Z","timestamp":1170493596000},"page":"166-170","source":"Crossref","is-referenced-by-count":22,"title":["Small pituitary size in children with Fanconi Anemia"],"prefix":"10.1002","volume":"49","author":[{"given":"Rosa","family":"Sherafat\u2010Kazemzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev N.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marguerite M.","family":"Care","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi\u2010Ok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan R.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"and the Fanconi Anemia Comprehensive Care Center","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,5]]},"reference":[{"volume-title":"Fanconi Anemia Standards for Clinical Care","year":"2003","author":"Owen J","key":"e_1_2_7_2_2"},{"key":"e_1_2_7_3_2","first-page":"381","article-title":"Fanconi's anemia\u2010endocrinopathies in association with structural central nervous system malformations","volume":"57","author":"Neelam Giri DB","year":"2005","journal-title":"Pediatr Res"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.109200"},{"key":"e_1_2_7_5_2","first-page":"551","article-title":"MR height of the pituitary gland as a function of age and sex: Especially physiological hypertrophy in adolescence and in climacterium","volume":"18","author":"Tsunoda A","year":"1997","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000053065"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.119174"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70482-2"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1558"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199701000-00006"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030135"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21148","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:38:28Z","timestamp":1699972708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,5]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1002\/pbc.21148"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21148","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2007,6,5]]}}}