{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:31:19Z","timestamp":1791955879745,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T00:00:00Z","timestamp":1169424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most survivors of childhood acute lymphoblastic leukemia (ALL) and T\u2010cell lymphoma (T\u2010NHL) treated before 1990 received cranial radiation. This study assessed the occurrence of second tumors in irradiated and non\u2010irradiated survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and ten survivors of ALL and T\u2010NHL were treated between 1974 and 1997 by several protocols. Imaging (MRI, CT) was performed every 3\u20136 years in 76\/88 irradiated and 74\/122 non\u2010irradiated patients for the last 20 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From January 1998 through 2004, meningiomas were detected in 16 survivors (8 female, 8 male) at age 20\u201339 years (median 28.7); 15 were asymptomatic. Cranial imaging done 2\u20138 years previously in 11 revealed no abnormalities. Fifteen had been diagnosed with ALL or T\u2010NHL 10\u201329 years earlier (median 21) and received cranial irradiation (24 Gy in 14) at age 2\u201314 years (median 7.6). Fifteen tumors arose in the convexity. Three patients had multiple lesions. Complete resection was performed in 12 patients, with one complication. One patient had a recurrence, and four with small tumors are under surveillance. Only one low\u2010grade glioma and two basal\u2010cell carcinomas were found. Only one of the 74 non\u2010irradiated patients (median follow\u2010up 14 years) developed meningioma. The Kaplan\u2010Meier estimate of incidence of meningioma was 14.8\u2009\u00b1\u20097.6 at 20 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Survivors of childhood ALL treated with cranial radiation require prolonged surveillance because of a high incidence of late meningiomas. Early detection, when the tumor is still small, facilitates resection and may reduce complications. Pediatr Blood Cancer 2007;49:294\u2013297. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21153","type":"journal-article","created":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T20:49:02Z","timestamp":1169498942000},"page":"294-297","source":"Crossref","is-referenced-by-count":67,"title":["High incidence of meningioma in cranial irradiated survivors of childhood acute lymphoblastic 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