{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:09:59Z","timestamp":1761487799816},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T00:00:00Z","timestamp":1173916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Institute of the McGill University Health Center-Montreal Children's Hospital."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Following outbreaks of meningococcal disease in Quebec in 1991\u20131993 and 2000\u20132001, a mass vaccination campaign was performed. In 2001\u20132002, children aged 2 months to 20 years were immunized with the Meningococcal CRM197 vaccine (Menjugate\u2122). We examined the response of pediatric oncology patients during or following maintenance chemotherapy and post\u2010bone\u2010marrow transplantation to Meningococcal C vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>This was an open label descriptive study of a cohort of patients from the oncology clinic at the Montreal Children's Hospital. A positive vaccine response was defined as a fourfold increase in specific IgG from baseline and a bactericidal assay using human complement (hBCA) titer &gt;1:4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 25 patients with ALL, 13 had a serologic response (average 60\u2010fold increase). The serologic responders had a higher mean B cell count (0.262) compared to non\u2010responders 0.068\u2009\u00d7\u200910.9\/L [<jats:italic>t<\/jats:italic>(23)\u2009=\u20092.843 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05)]. Eleven of the 12 non\u2010responders and 4 of the responders were on maintenance chemotherapy. In addition, two of the five patients post\u2010bone\u2010marrow transplant, responded. Fifteen of the 34 patients (44%) had an adequate hBCA response (mean titer 61). The group included 14\/18 serologic responders with hBCA response (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 16\/17 non\u2010serologic responders with no hBCA response (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Meningococcal C\u2010conjugate vaccine produced variable responses in children with common cancers. Proximity to chemotherapy and total B cell number may help predict likelihood of response. Pediatr Blood Cancer 2007;49:918\u2013923. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21174","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T15:35:37Z","timestamp":1173972937000},"page":"918-923","source":"Crossref","is-referenced-by-count":22,"title":["Immune response to conjugated meningococcal C vaccine in pediatric oncology patients"],"prefix":"10.1002","volume":"49","author":[{"given":"Joyce W.","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Borkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Danzig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce D.","family":"Mazer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,15]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1064","article-title":"Oh no, not another childhood vaccine","volume":"166","author":"Weir E","year":"2002","journal-title":"JAMC"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.5.383"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520290042027"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00252-4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200004000-00015"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105033441807"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00162-7"},{"key":"e_1_2_6_9_2","unstructured":"HudonN.La Meningite: 350000 jeunes Monteregiens seront vaccines cet automne. 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