{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:10:05Z","timestamp":1781683805261,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,4,9]],"date-time":"2007-04-09T00:00:00Z","timestamp":1176076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of our study was to evaluate the long\u2010term effects of chemotherapy and\/or radiotherapy on lung function in 75 childhood Hodgkin disease (HD) and non\u2010Hodgkin lymphoma (NHL) survivors several years after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>We studied 37 HD and 38 NHL survivors. These patients were divided into two groups according to the treatment protocols applied. Group I consisted of 23 patients who were treated with both chemotherapy and thoracic irradiation and Group II consisted of 52 patients who were treated with chemotherapy and no thoracic irradiation. A detailed history of smoking habits, respiratory symptoms, and diseases was recorded. Complete physical examinations and pulmonary function tests [PFT, including spirometry, lung volume, and diffusion capacity for carbon monoxide (DLCO)] were performed on all subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No patients reported acute or chronic respiratory symptoms or diseases. Pulmonary function abnormality (reduced lung volume and diffusion capacity) was found in 13% of patients at a median 5 years after diagnosis. The percentage of predicted normal value of forced expiratory volume in the 1st sec (FEV<jats:sub>1<\/jats:sub>), residual volume (RV), and DLCO were significantly lower in Group I than these values for Group II. There were no significant differences in PFT parameters between patients with HD and NHL (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). It appears that the risk of reduced lung function was greater the younger the patient in therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chemotherapy or chemo\u2010radiotherapy\u2010induced pulmonary sequalae in childhood may remain asymptomatic for many years. Pediatr Blood Cancer 2007;49:699\u2013703. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21175","type":"journal-article","created":{"date-parts":[[2007,4,9]],"date-time":"2007-04-09T19:47:28Z","timestamp":1176148048000},"page":"699-703","source":"Crossref","is-referenced-by-count":31,"title":["Long\u2010term pulmonary function in survivors of childhood Hodgkin disease and non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"49","author":[{"given":"Aynur","family":"Oguz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayyar","family":"Tayfun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvan Caglar","family":"Citak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceyda","family":"Karadeniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turkan","family":"Tatlicioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oznur","family":"Boyunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Bora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200107000-00006"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.4.1061"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-65-780-1114"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(78)90002-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.6.1478"},{"key":"e_1_2_5_7_2","first-page":"34","article-title":"The pulmonary toxicity of antineoplastic agents","volume":"9","author":"Ginsberg SJ","year":"1982","journal-title":"Semin Oncol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950180602"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90500-J"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(87)90066-6"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/oxfordjournals.annonc.a059221","article-title":"Lung function impairment in long\u2010term survivors of Hodgkin's disease","volume":"6","author":"Lund MB","year":"1995","journal-title":"Ann Oncol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200002000-00004"},{"key":"e_1_2_5_13_2","first-page":"4739","article-title":"Late pulmonary toxicity after treatment for Hodgkin's disease","volume":"17","author":"Villaini F","year":"1997","journal-title":"Anticancer Res"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058234"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(93)90382-P"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14025.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90485-9"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890215)63:4<625::AID-CNCR2820630404>3.0.CO;2-O"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10978"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.3.7663792"},{"key":"e_1_2_5_21_2","first-page":"3","article-title":"Standardization of lung function tests, European Community for Steel and Coal. 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