{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T09:21:10Z","timestamp":1724577670919},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,4,23]],"date-time":"2007-04-23T00:00:00Z","timestamp":1177286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Essential thrombocythemia is a rare myleoproliferative disorder in pediatrics. This myleoproliferative disorder is characterized by excessive proliferation of megakaryocytes and sustained elevation of platelet count. Reactive thrombocytosis is a more common cause of elevated platelet counts among children. We describe a 2\u2010year\u2010old child with essential thrombocythemia, skeletal anomalies, and elevated thrombopoietin concentrations. The child's mother was also subsequently diagnosed with essential thrombocythemia and had elevated thrombopoietin concentrations. Chromosomal studies on the mother, child and other family members were normal. Pediatr Blood Cancer 2008;50:859\u2013861. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21218","type":"journal-article","created":{"date-parts":[[2007,4,24]],"date-time":"2007-04-24T16:02:40Z","timestamp":1177430560000},"page":"859-861","source":"Crossref","is-referenced-by-count":5,"title":["Essential thrombocythemia in a child with elevated thrombopoietin concentrations and skeletal anomalies"],"prefix":"10.1002","volume":"50","author":[{"given":"Edwin B.","family":"Robins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massoma","family":"Niazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,23]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02239-7.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02270-7.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3471"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70363-9"},{"key":"e_1_2_4_6_2","first-page":"143","article-title":"Thrombocytosis in an infant with high thrombopoietin concentration","volume":"26","author":"Hankins J","year":"2004","journal-title":"Pediatr Hematol Oncol"},{"key":"e_1_2_4_7_2","first-page":"176","article-title":"Thrombopoietin levels in healthy children","volume":"3","author":"Kocak U","year":"2000","journal-title":"J Hellenic Soc Hematol"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71142-9"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.03.023"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01817.x"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.11.3280"},{"key":"e_1_2_4_12_2","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1182\/blood.V94.4.1480","article-title":"A single\u2010base deletion in the thrombopoietin (TPO) gene causes familial essential thrombocythemia through a mechanism of more efficient translation of TPO mRNA","volume":"94","author":"Ghilardi N","year":"1999","journal-title":"Blood"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-49"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050445"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01545.x"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401270"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504273321704"},{"key":"e_1_2_4_18_2","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1182\/blood.V90.9.3370","article-title":"Treatment of polycythemia vera: The use of hydroxyurea and piobroman in 292 patients under the age of 65 years","volume":"90","author":"Najean Y","year":"1997","journal-title":"Blood"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199806)30:6<367::AID-MPO13>3.0.CO;2-F"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90017-6"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2006.00719.x"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21218","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:52:53Z","timestamp":1697082773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,23]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/pbc.21218"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21218","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,23]]}}}