{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:26:22Z","timestamp":1784899582530,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,4,2]],"date-time":"2007-04-02T00:00:00Z","timestamp":1175472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Colorectal carcinoma (CRC) is one of the most common tumors in adults, but extremely rare in young age. This study retrospectively reports on a group of 27 patients &lt;30 years of age, and particularly on 7 cases &lt;18 years old, treated at the Istituto Nazionale Tumori, Milan, Italy, between 1985 and 2005.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Among the children\/adolescents (age 9\u201318, median 12 years), 5\/7 had unfavorable CRC histotypes (poorly differentiated or mucinous adenocarcinoma) and all but one had advanced disease at onset. Initial surgical resection was complete in 5\/7 cases, and all patients received postoperative chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the subset of patients &lt;18 years, 6\/7 had tumor progression or relapse, and 5 died of their tumor: overall survival (OS) was 23% at 5 years. In the group of 19\u2010 to 29\u2010year\u2010olds (young adults), 5\u2010year OS was 72.6%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study confirms the rarity and poor prognosis of CRC in children and adolescents: advanced stage and an aggressive biology are hallmarks of this tumor in pediatric age, while clinical findings and outcome in young adults seem more similar to those observed in adult series. Therapeutic recommendations should stay the same as for adults. Surgery remains the mainstay of treatment and early diagnosis is crucial: it is important for pediatricians to be aware that CRC does occur in children, in order to refer suspected cases to expert physicians professionally dedicated to the management of this cancer in adults. Pediatr Blood Cancer 2008;50:588\u2013593. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21220","type":"journal-article","created":{"date-parts":[[2007,4,2]],"date-time":"2007-04-02T18:17:50Z","timestamp":1175537870000},"page":"588-593","source":"Crossref","is-referenced-by-count":93,"title":["Colorectal carcinoma in children and adolescents: The experience of the Istituto Nazionale Tumori of Milan, Italy"],"prefix":"10.1002","volume":"50","author":[{"given":"Andrea","family":"Ferrari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Rognone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zaffignani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Piva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Collini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Bertario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermanno","family":"Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiberto","family":"Belli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Gallino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,9]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1172","volume-title":"Principles and Practice of Pediatric Oncology","author":"Pappo AS","year":"2006"},{"key":"e_1_2_5_3_2","unstructured":"RiesLEM KosaryC HankeyB et al.SEER cancer statistic review. 1975\u20132001.2004."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22012"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850315)55:6<1322::AID-CNCR2820550627>3.0.CO;2-5"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02389557"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199104000-00020"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(92)90565-O"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(92)90399-R"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80695-6"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-7404(96)80043-0"},{"key":"e_1_2_5_12_2","first-page":"441","article-title":"Cancer of the colon and rectum in the first three decades of life","volume":"44","author":"Shahrudin MD","year":"1997","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01076965"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00805.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(99)90112-4"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199906)32:6<459::AID-MPO17>3.0.CO;2-I"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199911)33:5<470::AID-MPO6>3.0.CO;2-A"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.4314\/cajm.v45i8.8486"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18548"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1097\/00007611-200194120-00015","article-title":"Colorectal cancer in patients 20 years old or less in Taiwan","volume":"94","author":"Chen LK","year":"2001","journal-title":"South Med J"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10194"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-38300"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.066092"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000149251.68562.8e"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(76)80075-9"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1071183"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0558-6"},{"key":"e_1_2_5_28_2","first-page":"409","article-title":"Adenocarcinoma of the colon and rectum in the adolescents","volume":"93","author":"Goldthorn JF","year":"1983","journal-title":"Surgery"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1602-y"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2004.00596.x"},{"key":"e_1_2_5_31_2","first-page":"607","article-title":"Colorectal cancer in young patients: Characteristics and outcome","volume":"60","author":"Lee PY","year":"1994","journal-title":"Am Surg"},{"key":"e_1_2_5_32_2","first-page":"849","article-title":"Colorectal cancer in the young patients","volume":"64","author":"Minardi AJ","year":"1998","journal-title":"Am Surg"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196709000-00010"},{"key":"e_1_2_5_34_2","unstructured":"AJCC Cancer Staging Manual 2002 Springer\u2010Verlag New York"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70510-X"},{"key":"e_1_2_5_37_2","article-title":"The challenge of very rare tumours in childhood: the Italian TREP project","author":"Ferrari A","year":"2006","journal-title":"Eur J Cancer"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990118)80:2<183::AID-IJC4>3.0.CO;2-W"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234737"},{"key":"e_1_2_5_40_2","first-page":"118","article-title":"Colorectal cancers under 45 years of age","volume":"51","author":"Zorluoglu A","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-7502-6_5"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197711)40:5 <2464::AID-CNCR2820400912>3.0.CO;2-D"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-002-0445-0"},{"key":"e_1_2_5_44_2","first-page":"4667","article-title":"Phase I\u2013II trial of high\u2010dose calcium leucovorin and 5\u2010fluorouracil in advanced colorectal cancer","volume":"44","author":"Madajewicz S","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.3109\/07357909509024888"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.126"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1159\/000091441"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431302"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00487-7"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.1.79"},{"key":"e_1_2_5_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5340.1043"},{"key":"e_1_2_5_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(96)00290-7"},{"key":"e_1_2_5_53_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-8_Part_1-200110160-00007"},{"key":"e_1_2_5_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3479843"},{"key":"e_1_2_5_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00223.x"},{"key":"e_1_2_5_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603318"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.21220","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.21220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T19:57:55Z","timestamp":1696881475000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.21220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,9]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/pbc.21220"],"URL":"https:\/\/doi.org\/10.1002\/pbc.21220","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,9]]}}}