{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:13:29Z","timestamp":1783178009960,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,5,18]],"date-time":"2007-05-18T00:00:00Z","timestamp":1179446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Charcot\u2013Marie\u2013Tooth (CMT) disease is the most common inherited peripheral neuropathy. Administration of vinca alkaloids is considered contraindicated in CMT because of the risk of life threatening acute neuropathy. We describe a 5\u2010year\u2010old patient with a family history of X\u2010linked CMT1 who presented with Wilms tumour. Despite confirmation of a connexin 32 point mutation, the patient was treated with 40.5 mg\/m<jats:sup>2<\/jats:sup> of vincristine with no clinical evidence of drug\u2010related neuropathy. This case describes vincristine being safely administered to a patient with molecularly proven type CMT 1X, but in type 1A CMT vincristine is still contraindicated. An extensive literature review revealed no other series of cases in which vincristine administration in molecularly proven CMT 1X had been described. CMT should be excluded in any patient who develops a profound, acute neuropathy following vincristine, as many patients in the cases reviewed were asymptomatic prior to treatment. Pediatr Blood Cancer 2008;50:874\u2013876. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/pbc.21221","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T12:07:27Z","timestamp":1179576447000},"page":"874-876","source":"Crossref","is-referenced-by-count":14,"title":["Uneventful administration of vincristine in Charcot\u2013Marie\u2013Tooth disease type 1X"],"prefix":"10.1002","volume":"50","author":[{"given":"Richa","family":"Ajitsaria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,18]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0492-29"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.11.014"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197206222862523"},{"key":"e_1_2_4_5_2","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1001\/jama.1984.03350200048021","article-title":"Polyneuropathy following vincristine therapy in two patients with Charcot\u2013Marie\u2013Tooth syndrome","volume":"252","author":"Hogan\u2010Dann CM","year":"1984","journal-title":"JAMA"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1985.03360040057019"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1985.tb123018.x"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880018809031253"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950170534"},{"key":"e_1_2_4_10_2","first-page":"709","article-title":"Charcot\u2013Marie\u2013Tooth disease disclosed by a treatment with vincristine in familial Hodgkin's disease","volume":"141","author":"Geny C","year":"1990","journal-title":"Ann Med Interne (Paris)"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950250212"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199604)26:4<280::AID-MPO12>3.0.CO;2-J"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1356::AID-CNCR20>3.0.CO;2-#"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.7556\/jaoa.1999.99.3.165"},{"key":"e_1_2_4_15_2","first-page":"414","article-title":"Acute vincristine neurotoxicity in a non\u2010Hodgkin's lymphoma patient with Charcot\u2013Marie\u2013Tooth disease","volume":"40","author":"Uno S","year":"1999","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.81.5.442"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008369315240"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03126.x"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10105"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000032505.45389.94"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200304000-00010"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-93-3-229"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20123"},{"key":"e_1_2_4_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000043691.53710.53"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8266101"},{"key":"e_1_2_4_26_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/hmg\/3.1.29","article-title":"Mutations in the connexin 32 gene in X\u2010linked dominant Charcot\u2013Marie\u2013Tooth disease (CMTX1)","volume":"3","author":"Fairweather N","year":"1994","journal-title":"Hum Mol Genet"},{"key":"e_1_2_4_27_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011124805315"}],"container-title":["Pediatric Blood &amp; 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