{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:14:49Z","timestamp":1769606089876,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,23]],"date-time":"2007-04-23T00:00:00Z","timestamp":1177286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the activity and tolerability of 2\u2010chlorodeoxyadenosine (2\u2010CDA) in treating mass lesions of the central nervous system (CNS) due to Langerhans cell histiocytosis (LCH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>The records of eight children and four adults with CNS LCH who were treated with 2\u2010CDA were reviewed. The pattern of CNS disease included involvement of the hypothalamic\u2010pituitary axis, gadolinium enhancing parenchymal as well as dural and choroid plexus based mass lesions, and atrophy. 2\u2010CDA (5\u201313 mg\/m<jats:sup>2<\/jats:sup>\/day) was given on 3\u20135 consecutive days and repeated every 2\u20138 weeks for a period ranging from 3 to 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight patients demonstrated a complete radiographic response to 2\u2010CDA with resolution of all enhancing mass lesions and four patients showed a sustained, partial radiographic response. One patient died from a non\u2010treatment related cause without evidence of LCH on autopsy. With a follow\u2010up ranging from 2 to 10 years after completion of therapy, the 11 surviving patients remain in continuous remission or are progression free. Prolonged bone marrow suppression was the most common toxicity (four patients). Permanent sequelae of CNS LCH, such as panhypopituitarism, diabetes insipidus (DI) and neurocognitive dysfunction, were not found to be reversible with 2\u2010CDA therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>2\u2010CDA is an active agent in patients with CNS LCH, with the possible exception of neurodegenerative disease, and should be further evaluated in a prospective multi\u2010center clinical trial for LCH patients with enhancing mass lesions of the CNS. Pediatr Blood Cancer 2008;50:72\u201379. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.21225","type":"journal-article","created":{"date-parts":[[2007,4,24]],"date-time":"2007-04-24T16:23:31Z","timestamp":1177431811000},"page":"72-79","source":"Crossref","is-referenced-by-count":72,"title":["Analysis of outcome for patients with mass lesions of the central nervous system due to Langerhans cell histiocytosis treated with 2\u2010chlorodeoxyadenosine"],"prefix":"10.1002","volume":"50","author":[{"given":"Girish","family":"Dhall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan L.","family":"Finlay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira J.","family":"Dunkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence J.","family":"Ettinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stewart J.","family":"Kellie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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